Recombinant Human IL-21

Code Description Price Qty
GFH90-2 Human IL-21, 2 μg $65.00
GFH90-10 Human IL-21, 10 μg $165.00
GFH90-100 Human IL-21, 100 μg $635.00
GFH90-1000 Human IL-21, 1 mg $5,240.00
Non-reducing (-) and reducing (+) conditions in a 4 - 20% Tris-Glycine gel stained with Coomassie Blue. 1 μg of protein was loaded in each lane. Human IL-21 has a predicted Mw of 15.4 kDa.

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Description

Interleukin-21 (IL-21) is a member of the common-γ chain family of cytokines that are involved in immunoregulation. IL-21 is normally expressed by activated CD4+ T cells and is aberrantly expressed in Hodgkin lymphoma cells. The IL-21 receptor (IL-21R) activates the JAK/STAT signaling pathway and is expressed on T, B, and Natural Killer (NK) cells. Within the B cell lineage, IL-21 is a switch factor regulating IgG1 and IgG3 antibody production. IL-21 also cooperates with IL-4 for the production of multiple antibody classes in B cells. IL-21 has pleiotropic effects on the proliferation, differentiation, and effector functions of B, T, NK, and dendritic cells.

Activity Assay

Human IL-21 is fully biologically active when compared to standard. The activity is determined by the ability to induce B9 cells proliferation and it is typically less than 50 ng/ml. This corresponds to an expected specific activity of 2.0 x 104 units/mg.

AA Sequence

MQDRHMIRMR QLIDIVDQLK NYVNDLVPEF LPAPEDVETN CEWSAFSCFQ KAQLKSANTG NNERIINVSI KKLKRKPPST NAGRRQKHRL TCPSCDSYEK KPPKEFLERF KSLLQKMIHQ HLSSRTHGSE DS

Alternative Names

Interleukin-21, interleukin 21, IL21, IL 21
Product Details
Length 132 aa
Molecular Weight 15.4 kDa
Structure Monomer
Source E. coli
Accession Number Q9HBE4
Purity ≥95% determined by reducing and non-reducing SDS-PAGE
Endotoxin Level ≤1.00 EU/μg as measured by kinetic LAL
Formulation Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)
Reconstitution Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile 10 mM HCI at 0.1 mg/ml, which can be further diluted into other aqueous solutions.
Stability and Storage

12 months from date of receipt when stored at -20°C to -80°C as supplied. 1 month when stored at 4°C after reconstituting as directed. 3 months when stored at -20°C to -80°C after reconstituting as directed.