Recombinant Human IL-22

Code Description Price Qty
GFH91-2 Human IL-22, 2 μg $65.00
GFH91-10 Human IL-22, 10 μg $165.00
GFH91-100 Human IL-22, 100 μg $635.00
GFH91-1000 Human IL-22, 1 mg $5,240.00
STAT3 phosphorylation is detectable starting at 1 ng/ml.
Reducing (+) conditions in a 4 - 20% Tris-Glycine gel stained with Coomassie Blue, 1 μg of protein was loaded. Human IL-22 has a predicted Mw of 33.8 kDa.

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Description

Interleukin-22 (IL-22) is an IL-10 family member that is produced by activated dendritic cells and T lymphocytes. IL-22 signals via a heteroduplex receptor consisting of IL-22R and IL-10Rβ chains. IL-22 is a potent mediator of cellular inflammatory responses.

Activity Assay

Human IL-22 is fully biologically active when compared to standard. The activity is determined by the ability to phosphorylate STAT3 when added to HepG2 cells.

AA Sequence

MAPISSHCRL DKSNFQQPYI TNRTFMLAKE ASLADNNTDV RLIGEKLFHG VSMSERCYLM KQVLNFTLEE VLFPQSDRFQ PYMQEVVPFL ARLSNRLSTC HIEGDDLHIQ RNVQKLKDTV KKLGESGEIK AIGELDLLFM SLRNACI

Alternative Names

Interleukin-12, interleukin 12, IL12, IL 12
Product Details
Length 147 / 294 aa
Molecular Weight 16.9 / 33.8 kDa
Structure Dimer
Source E. coli
Accession Number Q9GZX6
Purity ≥95% determined by reducing and non-reducing SDS-PAGE
Endotoxin Level ≤1.00 EU/μg as measured by kinetic LAL
Formulation Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium citrate, pH 3.0
Reconstitution Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile 10 mM HCI at 0.1 mg/ml, which can be further diluted into other aqueous solutions.
Stability and Storage

12 months from date of receipt when stored at -20°C to -80°C as supplied. 1 month when stored at 4°C after reconstituting as directed. 3 months when stored at -20°C to -80°C after reconstituting as directed.