Recombinant Human IL-31

Code Description Price Qty
GFH204-5 Human IL-31, 5 μg $65.00
GFH204-25 Human IL-31, 25 μg $165.00
GFH204-100 Human IL-31, 100 μg $820.00
GFH204-1000 Human IL-31, 1 mg $5,240.00

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Description

Interleukin-31 (IL-31) is an immunoregulatory cytokine that is expressed by activated type 2 T helper (Th2) cells. IL-31 signals through a heterodimer receptor consisting of the IL-31 Receptor A (IL-31RA) and the oncostatin M receptor (OSMR), which are expressed on monocytes, epithelial cells, and keratinocytes. IL-31 promotes allergic reactions and inflammatory skin diseases.

Activity Assay

Human IL-31 is fully biologically active when compared to standard. The activity is determined by the ability to induce STAT3 activation in U-87 MG cells detectable at lower than 25 ng/ml.

AA Sequence

SHTLPVRLLR PSDDVQKIVE ELQSLSKMLL KDVEEEKGVL VSQNYTLPCL SPDAQPPNNI HSPAIRAYLK TIRQLDNKSV IDEIIEHLDK LIFQDAPETN ISVPTDTHEC KRFILTISQQ FSECMDLALK SLTSGAQQAT T

Alternative Names

Interleukin-31, interleukin 31, IL31, IL 31
Product Details
Length 141 aa
Molecular Weight 15.8 kDa
Structure Monomer
Source E. coli
Accession Number Q6EBC2
Purity ≥95% determined by reducing and non-reducing SDS-PAGE
Endotoxin Level ≤1.00 EU/μg as measured by kinetic LAL
Formulation Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 20 mM sodium phosphate, 50 mM sodium chloride, pH 7.5
Reconstitution Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water at 0.1 mg/ml, which can be further diluted into other aqueous solutions.
Stability and Storage

12 months from date of receipt when stored at -20°C to -80°C as supplied. 1 month when stored at 4°C after reconstituting as directed. 3 months when stored at -20°C to -80°C after reconstituting as directed.