Recombinant Human IP-10 / CXCL10

Code Description Price Qty
GFH127-5 Human IP-10, 5 μg $65.00
GFH127-25 Human IP-10, 25 μg $165.00
GFH127-100 Human IP-10, 100 μg $410.00
GFH127-1000 Human IP-10, 1 mg $2,950.00
Induced chemotaxis of primary human T cells assay for Human IP-10. Cells that migrated were counted using a luminescent substrate. Migration over basal levels was reported in response to Human IP-10 starting at 5 ng/ml.
Non-reducing (-) and reducing (+) conditions in a 4 - 20% Tris-Glycine gel stained with Coomassie Blue. 1 μg of protein was loaded in each lane. Human IP-10 has a predicted Mw of 8.6 kDa.

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Description

Interferon γ-induced protein 10 (IP-10), also known as CXCL10, is a chemokine secreted by monocytes, endothelial cells and fibroblasts in response to interferon γ (IFN-γ). IP-10 functions as a chemoattractant for activated T cells, monocytes, dendritic, and Natural Killer (NK) cells that express the G protein-coupled receptor CXCR3. IP-10 is an important factor in autoimmune diseases such as Hashimoto's thyroiditis, Graves' disease, and Type 1 diabetes mellitus.

Activity Assay

Human IP-10 is fully biologically active when compared to standard. The activity is determined by the ability to induce chemotaxis of human primary T cells.

AA Sequence

VPLSRTVRCT CISISNQPVN PRSLEKLEII PASQFCPRVE IIATMKKKGE KRCLNPESKA IKNLLKAVSK ERSKRSP

Alternative Names

Monocyte Chemotactic Protein 1, CCL2, JE, MCAF
Product Details
Length 77 aa
Molecular Weight 8.6 kDa
Structure Monomer
Source E. coli
Accession Number P02778
Purity ≥95% determined by reducing and non-reducing SDS-PAGE
Endotoxin Level ≤1.00 EU/μg as measured by kinetic LAL
Formulation Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)
Reconstitution Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water at 0.1 mg/ml, which can be further diluted into other aqueous solutions.
Stability and Storage

12 months from date of receipt when stored at -20°C to -80°C as supplied. 1 month when stored at 4°C after reconstituting as directed. 3 months when stored at -20°C to -80°C after reconstituting as directed.