Recombinant Human ITAC / CXCL11

Code Description Price Qty
GFH128-5 Human ITAC, 5 μg $65.00
GFH128-20 Human ITAC, 20 μg $165.00
GFH128-100 Human ITAC, 100 μg $410.00
GFH128-1000 Human ITAC, 1 mg $2,950.00
Non-reducing (-) and reducing (+) conditions in a 4 - 20% Tris-Glycine gel stained with Coomassie Blue. 1 μg of protein was loaded in each lane. Human ITAC has a predicted Mw of 8.3 kDa.

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Description

Interferon-inducible T cell α chemoattractant (ITAC), also known as CXCL11, is expressed at high levels in leukocytes, pancreas, and liver cells. ITAC gene expression is induced by interferons α (IFN-α), β (IFN-β), and γ (IFN-γ). ITAC is the dominant ligand known to bind the chemokine receptor CXCR3, thus acting as a stronge agonist. ITAC functions as a chemoattractant for interleukin-2 (IL-2)-activated T cells.

Activity Assay

Human ITAC is fully biologically active when compared to standard. The activity is determined by the ability to chemoattract IL-2 activated T cells at a concentration of 0.1 - 10 ng/ml. There is no data currently available.

AA Sequence

FPMFKRGRCL CIGPGVKAVK VADIEKASIM YPSNNCDKIE VIITLKENKG QRCLNPKSKQ ARLIIKKVER KNF

Alternative Names

Interferon-inducible T cell α chemoattractant, CXCL11, B-R1, I-TAC, chemokine (C-X-C motif) ligand 11, C-X-C motif chemokine 11
Product Details
Length 73 aa
Molecular Weight 8.3 kDa
Structure Monomer
Source E. coli
Accession Number O14625
Purity ≥95% determined by reducing and non-reducing SDS-PAGE
Endotoxin Level ≤1.00 EU/μg as measured by kinetic LAL
Formulation Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)
Reconstitution Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water at 0.1 mg/ml, which can be further diluted into other aqueous solutions.
Stability and Storage

12 months from date of receipt when stored at -20°C to -80°C as supplied. 1 month when stored at 4°C after reconstituting as directed. 3 months when stored at -20°C to -80°C after reconstituting as directed.