Recombinant Human ITAC / CXCL11
Non-reducing (-) and reducing (+) conditions in a 4 - 20% Tris-Glycine gel stained with Coomassie Blue. 1 μg of protein was loaded in each lane. Human ITAC has a predicted Mw of 8.3 kDa.
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DescriptionInterferon-inducible T cell α chemoattractant (ITAC), also known as CXCL11, is expressed at high levels in leukocytes, pancreas, and liver cells. ITAC gene expression is induced by interferons α (IFN-α), β (IFN-β), and γ (IFN-γ). ITAC is the dominant ligand known to bind the chemokine receptor CXCR3, thus acting as a stronge agonist. ITAC functions as a chemoattractant for interleukin-2 (IL-2)-activated T cells.
Activity AssayHuman ITAC is fully biologically active when compared to standard. The activity is determined by the ability to chemoattract IL-2 activated T cells at a concentration of 0.1 - 10 ng/ml. There is no data currently available.
AA SequenceFPMFKRGRCL CIGPGVKAVK VADIEKASIM YPSNNCDKIE VIITLKENKG QRCLNPKSKQ ARLIIKKVER KNF
Alternative NamesInterferon-inducible T cell α chemoattractant, CXCL11, B-R1, I-TAC, chemokine (C-X-C motif) ligand 11, C-X-C motif chemokine 11
|Molecular Weight||8.3 kDa|
|Purity||≥95% determined by reducing and non-reducing SDS-PAGE|
|Endotoxin Level||≤1.00 EU/μg as measured by kinetic LAL|
|Formulation||Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)|
|Reconstitution||Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water at 0.1 mg/ml, which can be further diluted into other aqueous solutions.|
|Stability and Storage||
12 months from date of receipt when stored at -20°C to -80°C as supplied. 1 month when stored at 4°C after reconstituting as directed. 3 months when stored at -20°C to -80°C after reconstituting as directed.