Recombinant Human Pleiotrophin (Animal-Free)
Achieve Purchasing Synergy
Request a quote at [email protected] for 2 or more vials of any Growth Factor to receive a discount. Discounts range from 5 to 20% according to the size of your order.
PODS® Growth Factors
The product is currently not available as PODS®, please check back in the future.Animal-Free
This product is produced with no animal derived raw products. All processing and handling employs animal free equipment and animal free protocols.Description
Pleiotrophin is a heparin-binding growth factor that has mitogenic effects on fibroblast, epithelial, and endothelial cells. Pleiotrophin is made by many tissues, but is predominantly secreted by nervous tissue during development. Pleiotrophin induces neurite outgrowth and is involved in tumor growth and metastasis. Pleiotrophin binds with low affinity to the cell surface receptor nucleolin to inhibit HIV-1 infection and can also bind the receptor protein tyrosine phosphatase type Z (PTPRZ), syndecan-3, and anaplastic lymphoma kinase (ALK) receptors.Activity Assay
Human Pleiotrophin is fully biologically active when compared to standard. The activity is determined by the ability to induce neurite outgrowth of embryonic rat neuros at concentrations between 3 - 8 μg/ml. There is no data currently available.AA Sequence
MGKKEKPEKK VKKSDCGEWQ WSVCVPTSGD CGLGTREGTR TGAECKQTMK TQRCKIPCNW KKQFGAECKY QFQAWGECDL NTALKTRTGS LKRALHNAEC QKTVTISKPC GKLTKPKPQA ESKKKKKEGK KQEKMLDAlternative Names
PTN, HBBM, HBGF-8, NEGF1, HARP| Product Details | |
|---|---|
| Length | 137 aa |
| Molecular Weight | 15.4 kDa |
| Structure | Monomer |
| Source | E. coli |
| Accession Number | P21246 |
| Purity | ≥95% determined by reducing and non-reducing SDS-PAGE |
| Endotoxin Level | ≤1.00 EU/μg as measured by kinetic LAL |
| Formulation | Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium phosphate, pH 7.5 |
| Reconstitution | Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water at 0.1 mg/ml, which can be further diluted into other aqueous solutions. |
| Stability and Storage |
12 months from date of receipt when stored at -20°C to -80°C as supplied. 1 month when stored at 4°C after reconstituting as directed. 3 months when stored at -20°C to -80°C after reconstituting as directed. |
