Recombinant Human PlGF-3 (Animal-Free)

Code Description Price Qty
GFH198AF-5 Human PlGF-3 (Animal-Free), 5 μg $70.00
GFH198AF-25 Human PlGF-3 (Animal-Free), 25 μg $180.00
GFH198AF-100 Human PlGF-3 (Animal-Free), 100 μg $585.00
GFH198AF-1000 Human PlGF-3 (Animal-Free), 1 mg $3,245.00
Non-reducing (-) and reducing (+) conditions in a 4 - 20% Tris-Glycine gel stained with Coomassie Blue. 1 μg of protein was loaded in each lane. Human PlGF-3 is a dimer with a predicted Mw of 45.8 kDa (each monomer is 22.9 kDa).

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PODS® Growth Factors

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Animal-Free

This product is produced with no animal derived raw products. All processing and handling employs animal free equipment and animal free protocols.

Description

Placenta Growth Factor (PlGF) is a member of the Vascular Endothelial Growth Factor (VEGF) / Platelet-Derived Growth Factor (PDGF) family of growth factors that share a conserved pattern of eight cysteines. PlGF is detected in the placenta, heart, lungs, thyroid, and adipose tissues. These growth factors induce monocyte activation, migration, and production of inflammatory cytokines and VEGF. There are four alternatively spliced PlGF isoforms (PlGF-1, PlGF-2, PlGF-3, and PlGF-4), each with unique secretion patterns and heparin-binding affinities. PlGF-3 is an angiogenic factor, which promotes endothelial cell growth and angiogenesis, being expressed exclusively in the placenta.

Activity Assay

Activity to be determined.

AA Sequence

MLPAVPPQQW ALSAGNGSSE VEVVPFQEVW GRSYCRALER LVDVVSEYPS EVEHMFSPSC VSLLRCTGCC GDENLHCVPV ETANVTMQLL KIRSGDRPSY VELTFSQHVR CECRHSPGRQ SPDMPGDFRA DAPSFLPPRR SLPMLFRMEW GCALTGSQSA VWPSSPVPEE IPRMHPGRNG KKQQRKPLRE KMKPERCGDA VPRR

Alternative Names

Placenta Growth Factor-3, PGFL, Placenta Growth Factor, D12S1900, PGF, PGFL, placenta growth factor, placental growth factor, placental growth factor, vascular endothelial growth factor-related protein, PlGF, PlGF-2, PLGFplacental growth factor-like, SHGC-10760
Product Details
Length 204 / 408 aa
Molecular Weight 22.9 / 45.8 kDa
Structure Dimer
Source E. coli
Accession Number P49763
Purity ≥95% determined by reducing and non-reducing SDS-PAGE
Endotoxin Level ≤1.00 EU/μg as measured by kinetic LAL
Formulation Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)
Reconstitution Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water at 0.1 mg/ml, which can be further diluted into other aqueous solutions.
Stability and Storage

12 months from date of receipt when stored at -20°C to -80°C as supplied. 1 month when stored at 4°C after reconstituting as directed. 3 months when stored at -20°C to -80°C after reconstituting as directed.