Recombinant Human TSLP
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DescriptionThymic Stromal Lymphopoietin (TSLP) is a hematopoietic cytokine produced in several tissues including the heart, liver and prostate. TSLP induces the release of T-cell attracting chemokines from monocytes and regulates the maturation of myeloid and epidermal dendritic cells. TSLP signals through a heterodimeric receptor complex containing the TSLP receptor (TSLP-R/CRLF2) and IL-7R α chain.
Activity AssayHuman TSLP is fully biologically active when compared to standard. The activity is determined by the induced proliferation of BaF3 cells transiently expressing human IL-17Rα and human TSLP-R and it is typically 0.05 - 0.3 ng/ml. There is no data currently available.
AA SequenceMYDFTNCDFE KIKAAYLSTI SKDLITYMSG TKSTEFNNTV SCSNRPHCLT EIQSLTFNPT AGCASLAKEM FAMKTKAALA IWCPGYSETQ INATQAMKKR RKRKVTTNKC LEQVSQLQGL WRRFNRPLLK QQ
Alternative NamesThymic Stromal Lymphopoietin
|Molecular Weight||15.1 kDa|
|Purity||≥95% determined by reducing and non-reducing SDS-PAGE|
|Endotoxin Level||≤1.00 EU/μg as measured by kinetic LAL|
|Formulation||Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium phosphate, pH 7.5|
|Reconstitution||Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water at 0.1 mg/ml, which can be further diluted into other aqueous solutions.|
|Stability and Storage||
12 months from date of receipt when stored at -20°C to -80°C as supplied. 1 month when stored at 4°C after reconstituting as directed. 3 months when stored at -20°C to -80°C after reconstituting as directed.