Recombinant Mouse Follistatin

Code Description Price Qty
GFM24-5 Recombinant Mouse Follistatin, 5 μg £50.00
GFM24-20 Recombinant Mouse Follistatin, 20 μg £120.00
GFM24-100 Recombinant Mouse Follistatin, 100 μg £445.00
GFM24-100x10 Recombinant Mouse Follistatin, 100 μg x 10 £2,490.00
GFM24-1000 Recombinant Mouse Follistatin, 1 mg £2,490.00
Neutralization of Activin A induced cytotoxicity of MPC-11 cells assay for Mouse Follistatin. Cell proliferation was measured to calculate the ED50.

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Description

Follistatin is an autocrine, activin-binding protein that is ubiquitously expressed with highest expression levels being in the ovary and skin. Follistatin negatively regulates the signaling of Transforming Growth Factor β (TGF-β) family members, such as activin, bone morphogenic proteins (BMP), myostatin, Growth Differentiation Factor 11 (GDF-11), and TGF-β1. Follistatin functions as an antagonist by binding TGF-β family members to block interaction with their signaling receptors. Follistatin also inhibits the secretion of Follicle-Stimulating Hormone (FSH) from the anterior pituitary.

Activity Assay

Mouse Follistatin is fully biologically active when compared to standard. The activity is determined by the neutralization of Activin A.

AA Sequence

MGNCWLRQAK NGRCQVLYKT ELSKEECCST GRLSTSWTEE DVNDNTLFKW MIFNGGAPNC IPCKETCENV DCGPGKKCRM NKKNKPRCVC APDCSNITWK GPVCGLDGKT YRNECALLKA RCKEQPELEV QYQGRCKKTC RDVFCPGSST CVVDQTNNAY CVTCNRICPE PASSEQYLCG NDGVTYSSAC HLRKATCLLG RSIGLAYEGK CIKAKSCEDI QCTGGKKCLW DF

Alternative Names

FS, activin-binding protein, FSH-suppressing protein, FSP
Product Details
Length 289 aa
Molecular Weight 31.7 kDa
Structure Monomer
Source E. coli
Accession Number P19883
Purity ≥95% determined by reducing and non-reducing SDS-PAGE
Endotoxin Level ≤1.00 EU/μg as measured by kinetic LAL
Formulation Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium phosphate, 50 mM sodium chloride, pH 7.5
Reconstitution Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water at 0.1 mg/ml, which can be further diluted into other aqueous solutions.
Stability and Storage

12 months from date of receipt when stored at -20°C to -80°C as supplied. 1 month when stored at 4°C after reconstituting as directed. 3 months when stored at -20°C to -80°C after reconstituting as directed.