Recombinant Mouse IL-17A/F

Code Description Price Qty
GFM61-5 Mouse IL-17A/F, 5 μg $65.00
GFM61-25 Mouse IL-17A/F, 25 μg $165.00
GFM61-100 Mouse IL-17A/F, 100 μg $635.00
GFM61-1000 Mouse IL-17A/F, 1 mg $5,240.00
Induced production of Mouse IL-6 by NIH-3T3 cells. Production of mouse IL-6 was measured to calculate the ED50.

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Description

Interleukin-17A/F (IL-17A/F) is a heterodimer that is composed of the interleukin-17A (IL-17A) and interleukin-17F (IL-17F) members of the IL-17 family of cytokines. IL-17A/F is produced by T helper 17 cells (Th17) following interleukin-23 (IL-23) stimulation. IL-17A/F signals through the IL-17RA/IL-17RC receptor complex and functions to regulate inflammatory responses. IL-17A/F induces chemokine and airway neutrophilia production, similar in function to IL-17A and IL-17F homodimers. In regard to these functions, IL-17A/F is less active than the IL-17A homodimer and shows greater activity than the IL-17F homodimer. Human and rat IL-17A/F are active on mouse cells.

Activity Assay

Mouse IL-17A/F is fully biologically active when compared to standard. The activity is determined by the ability to produce mouse IL-6 by NIH-3T3 cells.

AA Sequence

IL-17A: MAAIIPQSSA CPNTEAKDFL QNVKVNLKVF NSLGAKVSSR RPSDYLNRST SPWTLHRNED PDRYPSVIWE AQCRHQRCVN AEGKLDHHMN SVLIQQEILV LKREPESCPF TFRVEKMLVG VGCTCVASIV RQAA IL-17F: MRKNPKAGVP ALQKAGNCPP LEDNTVRVDI RIFNQNQGIS VPREFQNRSS SPWDYNITRD PHRFPSEIAE AQCRHSGCIN A

Alternative Names

Interleukin-17A/F, heterodimeric interleukin-17A/F, IL17AF, IL-17AF
Product Details
Length 134 / 268 aa
Molecular Weight 30.1 kDa
Structure Dimer
Source E. coli
Accession Number Q62386/Q7TNI7
Purity ≥95% determined by reducing and non-reducing SDS-PAGE
Endotoxin Level ≤1.00 EU/μg as measured by kinetic LAL
Formulation Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)
Reconstitution Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile 10 mM HCI at 0.1 mg/ml, which can be further diluted into other aqueous solutions.
Stability and Storage

12 months from date of receipt when stored at -20°C to -80°C as supplied. 1 month when stored at 4°C after reconstituting as directed. 3 months when stored at -20°C to -80°C after reconstituting as directed.