Recombinant Mouse IL-2

Code Description Price Qty
GFM17-5 Mouse IL-2, 5 μg $75.00
GFM17-20 Mouse IL-2, 20 μg $189.00
GFM17-100 Mouse IL-2, 100 μg $469.00
GFM17-1000 Mouse IL-2, 1 mg $3,130.00
Induced proliferation of CTLL-2 cells for Mouse IL-2. Cell proliferation was measured to calculate the ED50, which is as expected less than 5 ng/ml.
Reducing (+) conditions in a 4 - 20% Tris-Glycine gel stained with Coomassie Blue, 1 μg of protein was loaded. Mouse IL-2 has a predicted Mw of 17.4 kDa.

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Description

Interleukin-2 (IL-2) is an immunomodulatory cytokine that is produced by lymphocytes. IL-2 signals through the IL-2R receptor to induce activated T cell proliferation and promote T cell differentiation. IL-2 also stimulates the proliferation and differentiation of B cells, Natural Killer cells, monocytes, and macrophages.

Activity Assay

Mouse IL-2 is fully biologically active when compared to standard. The activity is determined by the ability to induce CTLL-2 cells proliferation and it is typically less than 5 ng/ml. This corresponds to an expected specific activity of 2 x 105 units/mg.

AA Sequence

MAPTSSSTSS STAEAQQQQQ QQQQQQQHLE QLLMDLQELL SRMENYRNLK LPRMLTFKFY LPKQATELKD LQCLEDELGP LRHVLDLTQS KSFQLEDAEN FISNIRVTVV KLKGSDNTFE CQFDDESATV VDFLRRWIAF CQSIISTSPQ

Alternative Names

Interleukin-2, interleukin 2, IL2, IL 2, T cell growth factor, TCGF, Aldesleukin
Product Details
Length 150 aa
Molecular Weight 17.4 kDa
Structure Monomer
Source E. coli
Accession Number P04351
Purity ≥95% determined by reducing and non-reducing SDS-PAGE
Endotoxin Level ≤1.00 EU/μg as measured by kinetic LAL
Formulation Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium citrate, pH 4.0
Reconstitution Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile 10 mM acetic acid at 0.1 mg/ml, which can be further diluted into other aqueous solutions.
Stability and Storage

12 months from date of receipt when stored at -20°C to -80°C as supplied. 1 month when stored at 4°C after reconstituting as directed. 3 months when stored at -20°C to -80°C after reconstituting as directed.