Recombinant Mouse IL-22

Code Description Price Qty
GFM77-10 Mouse IL-22, 10 μg $189.00
GFM77-100 Mouse IL-22, 100 μg $728.00
GFM77-500 Mouse IL-22, 500 μg $3,536.00
GFM77-1000 Mouse IL-22, 1 mg $6,007.00
Induced production of IL-10 by human COLO-205 cells. Production of IL-10 was measured to calculate the ED50, which is as expected less than 1 ng/ml.
Non-reducing (-) and reducing (+) conditions in a 4 - 20% Tris-Glycine gel stained with Coomassie Blue. 1 μg of protein was loaded in each lane. Mouse IL-22 has a predicted Mw of 16.8 kDa.

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Description

Interleukin-22 (IL-22) is an IL-10 family member that is produced by activated dendritic cells and T lymphocytes. IL-22 signals via a heteroduplex receptor consisting of IL-22R and IL-10Rβ chains. IL-22 is a potent mediator of cellular inflammatory responses.

Activity Assay

Mouse IL-22 is fully biologically active when compared to standard. The activity is determined by the ability to induce production of IL-10 from human COLO-205 cells and it is typically less than 1 ng/ml. This corresponds to an expected specific activity of 1 x 106 units/mg.

AA Sequence

MLPVNTRCKL EVSNFQQPYI VNRTFMLAKE ASLADNNTDV RLIGEKLFRG VSAKDQCYLM KQVLNFTLED VLLPQSDRFQ PYMQEVVPFL TKLSNQLSSC HISGDDQNIQ KNVRRLKETV KKLGESGEIK AIGELDLLFM SLRNACV

Alternative Names

Interleukin-22, interleukin 22, IL22, IL 22, IL-TIF
Product Details
Length 147 aa
Molecular Weight 16.8 kDa
Structure Monomer
Source E. coli
Accession Number Q9JJY9
Purity ≥95% determined by reducing and non-reducing SDS-PAGE
Endotoxin Level ≤1.00 EU/μg as measured by kinetic LAL
Formulation Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)
Reconstitution Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water at 0.1 mg/ml, which can be further diluted into other aqueous solutions.
Stability and Storage

12 months from date of receipt when stored at -20°C to -80°C as supplied. 1 month when stored at 4°C after reconstituting as directed. 3 months when stored at -20°C to -80°C after reconstituting as directed.