Recombinant Mouse IL-31

Code Description Price Qty
GFM71-2 Mouse IL-31, 2 μg $65.00
GFM71-10 Mouse IL-31, 10 μg $165.00
GFM71-100 Mouse IL-31, 100 μg $635.00
GFM71-1000 Mouse IL-31, 1 mg $5,240.00
Induced production of IL-8 from human PBMC cells for Mouse IL-31. Cell proliferation was measured to calculate the ED50, which was 20 - 30 ng/ml.

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Description

Interleukin-31 (IL-31) is an immunoregulatory cytokine that is expressed by activated type 2 T helper (Th2) cells. IL-31 signals through a heterodimer receptor consisting of the IL-31 Receptor A (IL-31RA) and the oncostatin M receptor (OSMR), which are expressed on monocytes, epithelial cells, and keratinocytes. IL-31 promotes allergic reactions and inflammatory skin diseases.

Activity Assay

Mouse IL-31 is fully biologically active when compared to standard. The activity is determined by the induced production of IL-8 from human PBMC cells.

AA Sequence

MTCSLSFGAP ISKEDLRTTI DLLKQESQDL YNNYSIKQAS GMSADESIQL PCFSLDREAL TNISVIIAHL EKVKVLSENT VDTSWVIRWL TNISCFNPLN LNISVPGNTD ESYDCKVFVL TVLKQFSNCM AELQAKDNTT C

Alternative Names

Interleukin-31, interleukin 31, IL31, IL 31
Product Details
Length 141 aa
Molecular Weight 15.7 kDa
Structure Monomer
Source E. coli
Accession Number Q6EAL8
Purity ≥95% determined by reducing and non-reducing SDS-PAGE
Endotoxin Level ≤1.00 EU/μg as measured by kinetic LAL
Formulation Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium phosphate, pH 7.5
Reconstitution Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water at 0.1 mg/ml, which can be further diluted into other aqueous solutions.
Stability and Storage

12 months from date of receipt when stored at -20°C to -80°C as supplied. 1 month when stored at 4°C after reconstituting as directed. 3 months when stored at -20°C to -80°C after reconstituting as directed.