Recombinant Mouse IL-36 γ

Code Description Price Qty
GFM81-5 Mouse IL-36 γ, 5 μg $65.00
GFM81-20 Mouse IL-36 γ, 20 μg $165.00
GFM81-100 Mouse IL-36 γ, 100 μg $600.00
GFM81-1000 Mouse IL-36 γ, 1 mg $5,240.00
Non-reducing (-) and reducing (+) conditions in a 4 - 20% Tris-Glycine gel stained with Coomassie Blue. 1 μg of protein was loaded in each lane. Mouse IL-36 γ has a predicted Mw of 17.5 kDa.

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Description

Interleukin-36 γ (IL-36 γ) is a member of the interleukin-1 (IL-1) cytokine family and protects against pathogens in the skin, lung, and stomach epithelial barriers. IL-36G binds the interleukin-1 receptor accessory protein (IL-1RAcP) and the orphan IL-1R-related protein 2 (IL-1Rrp2) receptors to activate NF-kappaB and MAP kinase signaling pathways, resulting in the induced production of inflammatory cytokines and chemokines.

Activity Assay

Activity to be determined.

AA Sequence

MGRETPDFGE VFDLDQQVWI FRNQALVTVP RSHRVTPVSV TILPCKYPES LEQDKGIAIY LGIQNPDKCL FCKEVNGHPT LLLKEEKILD LYHHPEPMKP FLFYHTRTGG TSTFESVAFP GHYIASSKTG NPIFLTSKKG EYYNINFNLD IKS

Alternative Names

IL-1F9, IL-1 epsilon, interleukin-36, interleukin 36, IL36, IL 36 γ
Product Details
Length 153 aa
Molecular Weight 17.5 kDa
Structure Monomer
Source E. coli
Accession Number Q8R460
Purity ≥95% determined by reducing and non-reducing SDS-PAGE
Endotoxin Level ≤1.00 EU/μg as measured by kinetic LAL
Formulation Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)
Reconstitution Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile 10 mM HCI at 0.1 mg/ml, which can be further diluted into other aqueous solutions.
Stability and Storage

12 months from date of receipt when stored at -20°C to -80°C as supplied. 1 month when stored at 4°C after reconstituting as directed. 3 months when stored at -20°C to -80°C after reconstituting as directed.