Recombinant Mouse IL-7 (Animal-Free)
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PODS® Growth Factors
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This product is produced with no animal derived raw products. All processing and handling employs animal free equipment and animal free protocols.Description
Interleukin-7 (IL-7) is a hematopoietic cytokine that is an important regulator of B and T cell development. IL-7 is secreted by bone marrow and thymic stromal cells, dendritic cells, intestinal epithelial cells, hepatocytes, and keratinocytes. IL-7 signals through the interleukin-7 receptor (IL-7R) to promote the differentiation of hematopoietic stem cells into T cells, B cells, and Natural Killer cells. IL-7 is also a regulator of intestinal mucosal lymphocyte proliferation. Human and mouse IL-7 show species cross-reactivity.Activity Assay
Mouse IL-7 is fully biologically active when compared to standard. The activity is determined by the ability to induce mouse 2E8 cells proliferation and it is typically less than 1 ng/ml. This corresponds to an expected specific activity of 1 x 106 units/mg.AA Sequence
MECHIKDKEG KAYESVLMIS IDELDKMTGT DSNCPNNEPN FFRKHVCDDT KEAAFLNRAA RKLKQFLKMN ISEEFNVHLL TVSQGTQTLV NCTSKEEKNV KEQKKNDACF LKRLLREIKT CWNKILKGSIAlternative Names
Interleukin-7, interleukin 7, IL7, IL 7, lymphopoietin 1, LP-1, pre-B cell factor| Product Details | |
|---|---|
| Length | 130 aa |
| Molecular Weight | 15 kDa |
| Structure | Monomer |
| Source | E. coli |
| Accession Number | P10168 |
| Purity | ≥95% determined by reducing and non-reducing SDS-PAGE |
| Endotoxin Level | ≤1.00 EU/μg as measured by kinetic LAL |
| Formulation | Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA) |
| Reconstitution | Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile 10 mM acetic acid at 0.1 mg/ml, which can be further diluted into other aqueous solutions. |
| Stability and Storage |
12 months from date of receipt when stored at -20°C to -80°C as supplied. 1 month when stored at 4°C after reconstituting as directed. 3 months when stored at -20°C to -80°C after reconstituting as directed. |
