Recombinant Mouse Leptin

Code Description Price Qty
GFM26-200 Mouse Leptin, 200 μg $65.00
GFM26-1000 Mouse Leptin, 1 mg $165.00
GFM26-5000 Mouse Leptin, 5 mg $490.00
GFM26-10000 Mouse Leptin, 10 mg $885.00
Induced proliferation of Baf/3 cells for Leptin. Cell proliferation was measured to calculate the ED50.

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Description

Leptin is a hormone that is produced by adipose tissue and plays critical roles in the physiologic regulation of body weight. Leptin acts through the leptin receptor (LEPR) to regulate adipose mass by inhibiting hunger and balancing energy usage. Leptin mutations cause severe hereditary obesity and hypogonadism in rodents and humans. Leptin also has thermogenic actions, regulates enzymes of fatty acid oxidation, and is involved in hematopoiesis, angiogenesis, wound healing, inflammation, and immune responses.

Activity Assay

Mouse Leptin is fully biologically active when compared to standard. The activity is determined by the ability to induce Baf/3 cells proliferation.

AA Sequence

MVPIHKVQDD TKTLIKTIVT RINDISHTQS VSARQRVTGL DFIPGLHPIL SLSKMDQTLA VYQQILTSLP SQNVLQIAHD LENLRDLLHL LAFSKSCSLP QTRGLQKPES LDGVLEASLY STEVVALSRL QGSLQDILQQ LDLSPEC

Alternative Names

Obesity protein, OBS
Product Details
Length 147 aa
Molecular Weight 16.3 kDa
Structure Dimer
Source E. coli
Accession Number P50596
Purity ≥95% determined by reducing and non-reducing SDS-PAGE
Endotoxin Level ≤1.00 EU/μg as measured by kinetic LAL
Formulation Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)
Reconstitution Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water at 0.1 mg/ml, which can be further diluted into other aqueous solutions.
Stability and Storage

12 months from date of receipt when stored at -20°C to -80°C as supplied. 1 month when stored at 4°C after reconstituting as directed. 3 months when stored at -20°C to -80°C after reconstituting as directed.