Recombinant Mouse NGF-β (Animal-Free)

Code Description Price Qty
GFM11AF-5 Mouse NGF-β (Animal-Free), 5 μg $70.00
GFM11AF-20 Mouse NGF-β (Animal-Free), 20 μg $180.00
GFM11AF-100 Mouse NGF-β (Animal-Free), 100 μg $455.00
GFM11AF-1000 Mouse NGF-β (Animal-Free), 1 mg $3,245.00

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PODS® Growth Factors

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Animal-Free

This product is produced with no animal derived raw products. All processing and handling employs animal free equipment and animal free protocols.

Description

Nerve Growth Factor β (NGF-β) is a neurotrophic factor that is important for the development and maintenance of sensory and sympathetic neurons. NGF-β signals through the low affinity nerve growth factor receptor (LNGFR) and the tropomyosin receptor kinase A (TrkA) to activate PI3K, Ras, and PLC signaling pathways. NGF-β is also involved in the growth, differentiation, and survival of B lymphocytes. Human, mouse, and rat NGF-β proteins are cross-reactive.

Activity Assay

Mouse NGF-β (Animal-Free) is fully biologically active when compared to standard. The activity is determined by the ability to induce TF-1 cells proliferation and it is typically less than 5 ng/ml. This corresponds to an expected specific activity of 2.0 x 105 units/mg.

AA Sequence

MSSTHPVFHM GEFSVCDSVS VWVGDKTTAT DIKGKEVTVL AEVNINNSVF RQYFFETKCR ASNPVESGCR GIDSKHWNSY CTTTHTFVKA LTTDEKQAAW RFIRIDTACV CVLSRKATRR G

Alternative Names

Nerve Growth Factor β, β-nerve growth factor, bNGF, NGFB
Product Details
Length 121 / 242 aa
Molecular Weight 13.6 / 27.2 kDa
Structure Dimer
Source E. coli
Accession Number Q6LDU8
Purity ≥95% determined by reducing and non-reducing SDS-PAGE
Endotoxin Level ≤1.00 EU/μg as measured by kinetic LAL
Formulation Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)
Reconstitution Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water at 0.1 mg/ml, which can be further diluted into other aqueous solutions.
Stability and Storage

12 months from date of receipt when stored at -20°C to -80°C as supplied. 1 month when stored at 4°C after reconstituting as directed. 3 months when stored at -20°C to -80°C after reconstituting as directed.