Recombinant Rat IL-10 (Animal-Free)

Code Description Price Qty
GFR35AF-5 Rat IL-10 (Animal-Free), 5 μg $70.00
GFR35AF-20 Rat IL-10 (Animal-Free), 20 μg $180.00
GFR35AF-100 Rat IL-10 (Animal-Free), 100 μg $700.00
GFR35AF-1000 Rat IL-10 (Animal-Free), 1 mg $5,765.00
Non-reducing (-) and reducing (+) conditions in a 4 - 20% Tris-Glycine gel stained with Coomassie Blue. 1 μg of protein was loaded in each lane. Rat IL-10 has a predicted Mw of 18.8 kDa.

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PODS® Growth Factors

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Animal-Free

This product is produced with no animal-derived raw products. All processing and handling employs animal-free equipment and animal-free protocols.

Description

Interleukin-10 (IL-10) is an anti-inflammatory cytokine produced by macrophages and type 2 T helper (Th2) cells. IL-10 inhibits the production of pro-inflammatory cytokines such as interferon-γ (IFN-γ), Tumor Necrosis Factor α (TNF-α), interleukin-2 (IL-2), interleukin-3 (IL-3), interleukin-4 (IL-4), and Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF), made by macrophages and regulatory T cells. IL-10 also suppresses antigen presentation on antigen presenting cells, and enhances the survival, proliferation, and antibody production of B cells.

Activity Assay

Activity to be determined.

AA Sequence

MSKGHSIRGD NNCTHFPVSQ THMLRELRAA FSQVKTFFQK KDQLDNILLT DSLLQDFKGY LGCQALSEMI KFYLVEVMPQ AENHGPEIKE HLNSLGEKLK TLWIQLRRCH RFLPCENKSK AVEQVKNDFN KLQDKGVYKA MNEFDIFINC IEAYVTLKMK N

Alternative Names

Interleukin-10, interleukin 10, IL10, IL 10, B-TCGF, CSIF, TGIF, cytokine synthesis inhibitory factor
Product Details
Length 161 aa
Molecular Weight 18.8 kDa
Structure Monomer
Source E. coli
Accession Number P29456
Purity ≥95% determined by reducing and non-reducing SDS-PAGE
Endotoxin Level ≤1.00 EU/μg as measured by kinetic LAL
Formulation Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)
Reconstitution Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water at 0.1 mg/ml, which can be further diluted into other aqueous solutions.
Stability and Storage

12 months from date of receipt when stored at -20°C to -80°C as supplied. 1 month when stored at 4°C after reconstituting as directed. 3 months when stored at -20°C to -80°C after reconstituting as directed.