Recombinant Rat IL-6

Code Description Price Qty
GFR9-2 Rat IL-6, 2 μg $65.00
GFR9-10 Rat IL-6, 10 μg $165.00
GFR9-100 Rat IL-6, 100 μg $635.00
GFR9-1000 Rat IL-6, 1 mg $5,240.00

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Description

Interleukin-6 (IL-6) is a cytokine that is expressed by T cells, macrophages, and muscle cells. IL-6 acts to stimulate an immune response upon infection or trauma. IL-6 has both pro-inflammatory and anti-inflammatory functions and signals through the cell-surface type 1 cytokine receptor complex containing the IL-6Ra and gp130 chains. Human IL-6 is active on mouse and rat cells.

Activity Assay

Rat IL-6 is fully biologically active when compared to standard. The activity is determined by the ability to induce B9 cells proliferation and it is typically less than 2 ng/ml. This corresponds to an expected specific activity of 5.0 x 105 units/mg.

AA Sequence

MFPTSQVRRG DFTEDTTHNR PVYTTSQVGG LITYVLREIL EMRKELCNGN SDCMNSDDAL SENNLKLPEI QRNDGCFQTG YNQEICLLKI CSGLLEFRFY LEFVKNNLQD NKKDKARVIQ SNTETLVHIF KQEIKDSYKI VLPTPTSNAL LMEKLESQKE WLRTKTIQLI LKALEEFLKV TMRSTRQT

Alternative Names

Interleukin-6, interleukin 6, IL6, IL 6, IFN-β2, interferon β 2, B-cell differentiation factor, BSF-2, HSF, MGI-2, CTL differentiation factor
Product Details
Length 188 aa
Molecular Weight 21.9 kDa
Structure Monomer
Source E. coli
Accession Number P20607
Purity ≥90% determined by reducing and non-reducing SDS-PAGE
Endotoxin Level ≤1.00 EU/μg as measured by kinetic LAL
Formulation Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA) and mannitol (2:1 mannitol to protein ratio)
Reconstitution Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile 10 mM HCI at 0.1 mg/ml, which can be further diluted into other aqueous solutions.
Stability and Storage

12 months from date of receipt when stored at -20°C to -80°C as supplied. 1 month when stored at 4°C after reconstituting as directed. 3 months when stored at -20°C to -80°C after reconstituting as directed.