A769662

Code Description Price Qty
SM08-2 A769662, 2 mg £30.00
SM08-10 A769662, 10 mg £85.00
SM08-50 A769662, 50 mg £350.00
SM08-200 A769662, 200 mg £985.00
A769662

Exact Amount™

The mg quantity of material provided in the smallest pack size for this product is specified on the vial label to two decimal places. This reduces concentration variation and ensures reproducibility in your experiments.

Activity

A769662 is a potent, reversible activator of AMP-activated protein kinase (AMPK). It activates beta1-containing AMPK complexes, but induces glucose uptake via a PI3 kinase-dependent pathway.

Effect

A769662 inhibits 3T3-L1 adipocyte differentiation and may be used to treat obesity. It also inhibited the function of the 26S proteasome via an AMPK-independent mechanism.

Alternative Names

A-769662

6,7-Dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile

References

1. Göransson, O., et al. 2007. J. Biol. Chem. 282: 32549-32560. PMID: 17855357

2. Treebak, J.T., et al. 2009. Am. J. Physiol. Cell Physiol. 297: 1041-1052. PMID: 19657063

3. Benziane, B., et al. 2009. Am. J. Physiol. Cell Physiol. 297: 1554-1566. PMID: 19828836

4. Rajamohan, F., et al. 2010. Protein Expr. Purif. 73: 189-197. PMID: 20451617

Product Details
Formula C20H12N2O3S
Molecular Weight 360.39
CAS Number 844499-71-4
Purity >99%
Solubility DMSO, ethanol
Stability and Storage Stable at -20°C. Keep away from direct sunlight.