ALK5 Inhibitor II

Code Description Price Qty
SM09-1 ALK5 Inhibitor II, 1 mg $60.00
SM09-5 ALK5 Inhibitor II, 5 mg $175.00
SM09-10 ALK5 Inhibitor II, 10 mg $218.00
SM09-25 ALK5 Inhibitor II, 25 mg $388.00
SM09-50 ALK5 Inhibitor II, 50 mg $535.00
ALK5 Inhibitor II

Exact Amount™

The mg quantity of material provided in the smallest pack size for this product is specified on the vial label to two decimal places. This reduces concentration variation and ensures reproducibility in your experiments.


ALK5 Inhibitor II is a cell permeable, potent, selective and ATP-competitive inhibitor of TGF-β RI kinase (IC50 = 23 nM, 4 nM and 18 nM for binding, auto-phosphorylation and cellular assay in HepG2 cells of TGF-β RI kinase, respectively). TGF-β RI (ALK5) Inhibitor II affects a panel of 9 closely related kinases including p38 MAPK.


ALK5 can replace Sox2 for generation of induced pluripotent stem cells (iPSC).

Alternative Names

TGF-beta RI Kinase Inhibitor II, TGF beta RI Kinase Inhibitor II, RepSox, 2-(3-(6-methylpyridine-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine


1. Gellibert, F., et al. 2004. J Med Chem 47: 4494-4506. PMID: 15317461

2. Ichida, J.K., et al. 2009. Cell Stem Cell 5: 491-503. PMID: 19818703

Product Details
Formula C17H13N5
Molecular Weight 287.32
CAS Number 446859-33-2
Purity >98%
Solubility DMSO
Stability and Storage Stable at -20°C. Keep away from direct sunlight.