BI-D1870

Code Description Price Qty
SM10-1 BI-D1870, 1 mg £30.00
SM10-5 BI-D1870, 5 mg £85.00
SM10-10 BI-D1870, 10 mg £150.00
BI-D1870

Exact Amount™

The mg quantity of material provided in the smallest pack size for this product is specified on the vial label to two decimal places. This reduces concentration variation and ensures reproducibility in your experiments.

Activity

BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms, which inhibits RSK1, RSK2, RSK3 and RSK4 in-vitro. BI-D1870 does not significantly inhibit ten other AGC kinase members and over 40 other protein kinases tested at 100-fold higher concentrations. BI-D1870 does not affect the agonist-triggered phosphorylation of substrates for six other AGC kinases. Additionally, BI-D1870 does not suppress the phorbol ester- or EGF-induced phosphorylation of CREB (cAMP-response-element-binding protein).

Effect

BI-D1870 induces apoptosis, although preferentially, in a p21-deficient background. BI-D1870 also induces a strong transcription and p53-independent accumulation of p21 protein and protects cells from gamma irradiation-induced apoptosis, driving them into senescence even in the absence of gamma irradiation.

Alternative Names

2-[(3,5-Difluoro-4-hydroxyphenyl)amino]-7,8-dihydro-5,7-dimethyl-8-(3-methylbutyl)-6(5H)-pteridone

References

1. Neise, D., et al. 2013. Cell Death and Disease. 4: e859. PMID: 24136223

Product Details
Formula C19H23F2N5O2
Molecular Weight 391.42
CAS Number 501437-28-1
Purity >97%
Solubility DMSO
Stability and Storage Stable at -20°C. Keep away from direct sunlight.