BIRB796

Code Description Price Qty
SM11-2 BIRB796, 2 mg £30.00
SM11-10 BIRB796, 10 mg £85.00
SM11-25 BIRB796, 25 mg £160.00
SM11-50 BIRB796, 50 mg £325.00
SM11-100 BIRB796, 100 mg £510.00
BIRB796

Exact Amount™

The mg quantity of material provided in the smallest pack size for this product is specified on the vial label to two decimal places. This reduces concentration variation and ensures reproducibility in your experiments.

Activity

BIRB796 is a protein kinase inhibitor of p38 MAPK. BIRB796 has high picomolar affinity for p38 MAP kinase and low nanomolar inhibitory activity against TNF-alpha in THP-1 cell culture. The p38 inhibitor BIRB796 binds tightly to ABL(T315I) and inhibits the BMS-354825 and imatinib-resistant ABL(T315I) kinase.

Effect

BIRB796 has been used as part of the naive human stem cell (NSHM) medium to create naive state human cells.

Alternative Names

Doramapimod, BIRB-796, BIRB 796, 285983-48-4, S1574_Selleck, Kinome_2137, 1kv2, UNII-HO1A8B3YVV, Doramapimod (USAN/INN)

1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)naphthalen-1-yl]urea

References

1. Gafni, O., et al. 2013. Nature. 504(7479): 282-286. PMID: 24172903

Product Details
Formula C31H37N5O3
Molecular Weight 527.66
CAS Number 285983-48-4
Purity >99%
Solubility DMSO, ethanol
Stability and Storage Stable at -20°C. Keep away from direct sunlight.