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BIRB796 is a protein kinase inhibitor of p38 MAPK. BIRB796 has high picomolar affinity for p38 MAP kinase and low nanomolar inhibitory activity against TNF-alpha in THP-1 cell culture. The p38 inhibitor BIRB796 binds tightly to ABL(T315I) and inhibits the BMS-354825 and imatinib-resistant ABL(T315I) kinase.
BIRB796 has been used as part of the naive human stem cell (NSHM) medium to create naive state human cells.
Doramapimod, BIRB-796, BIRB 796, 285983-48-4, S1574_Selleck, Kinome_2137, 1kv2, UNII-HO1A8B3YVV, Doramapimod (USAN/INN)
1. Gafni, O., et al. 2013. Nature. 504(7479): 282-286. PMID: 24172903