BIX01294 Trihydrochloride Hydrate

Code Description Price Qty
SM12-2 BIX01294 TriHydrochloride Hydrate, 2 mg £30.00
SM12-10 BIX01294 TriHydrochloride Hydrate, 10 mg £85.00
SM12-50 BIX01294 TriHydrochloride Hydrate, 50 mg £540.00
BIX01294 Trihydrochloride Hydrate

Exact Amount™

The mg quantity of material provided in the smallest pack size for this product is specified on the vial label to two decimal places. This reduces concentration variation and ensures reproducibility in your experiments.

Activity

BIX01294 is a G9a-like protein and G9a histone lysine methyltransferase inhibitor (IC50 values are 0.7 and 1.7 μM, respectively) that displays no activity at other histone methyltransferases up to 37 μM.

Effect

BIX01294 modulates H3K9me2 levels in mammalian cells and potentiates induction of pluripotent stem cells from somatic cells in-vitro.

Alternative Names

BIX 01294, BIX-01294

2-(Hexahydro-4-methyl-1H-1, 4-diazepin-1-yl)-6, 7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine trihydrochloride

References

1. Tachibana, M., et al., 2002. Genes Dev. 16(14): 1779-1791. PMID: 12130538

2. Wagschal, A., et al. 2008. Mol Cell Biol. 28(3) 1104-1113. PMID: 18039842

3. Thomas, L.R., et al. 2008. J Immunol. 181(1): 485-493. PMID: 18566414

4. Kubicek, S., et al. 2007. Mol Cell. 25(3): 473-481. PMID: 17289593 5. Shi, Y., et al. 2008. Cell Stem Cell. 3(5): 568-574. PMID: 18983970

Product Details
Formula C28H38N6O2.3HCl
Molecular Weight 600.02
CAS Number 1392399-03-9
Purity >98%
Solubility DMSO, water
Stability and Storage Stable at -20°C. Keep away from direct sunlight.