BIX01294 Trihydrochloride Hydrate
Exact Amount™
The mg quantity of material provided in the smallest pack size for this product is specified on the vial label to two decimal places. This reduces concentration variation and ensures reproducibility in your experiments.Activity
BIX01294 is a G9a-like protein and G9a histone lysine methyltransferase inhibitor (IC50 values are 0.7 and 1.7 μM, respectively) that displays no activity at other histone methyltransferases up to 37 μM.
Effect
BIX01294 modulates H3K9me2 levels in mammalian cells and potentiates induction of pluripotent stem cells from somatic cells in-vitro.
Alternative Names
BIX 01294, BIX-01294
2-(Hexahydro-4-methyl-1H-1, 4-diazepin-1-yl)-6, 7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine trihydrochloride
References
1. Tachibana, M., et al., 2002. Genes Dev. 16(14): 1779-1791. PMID: 12130538
2. Wagschal, A., et al. 2008. Mol Cell Biol. 28(3) 1104-1113. PMID: 18039842
3. Thomas, L.R., et al. 2008. J Immunol. 181(1): 485-493. PMID: 18566414
4. Kubicek, S., et al. 2007. Mol Cell. 25(3): 473-481. PMID: 17289593 5. Shi, Y., et al. 2008. Cell Stem Cell. 3(5): 568-574. PMID: 18983970
| Product Details | |
|---|---|
| Formula | C28H38N6O2.3HCl |
| Molecular Weight | 600.02 |
| CAS Number | 1392399-03-9 |
| Purity | >98% |
| Solubility | DMSO, water |
| Stability and Storage | Stable at -20°C. Keep away from direct sunlight. |
