Cyclosporin A

Code Description Price Qty
SM43-50 Cyclosporin A, 50 mg £30.00
SM43-1000 Cyclosporin A, 1 g £85.00
SM43-5000 Cyclosporin A, 5 g £235.00
Cyclosporin A

Activity

Cyclosporin A is a non-polar cyclic oligopeptide metabolite. It possesses potent immunosuppressive properties, affecting primarly T-lymphocytes. Cyclosporin A is the primary tool used to prevent rejection following solid organ and/or bone marrow transplantation.

Effect

Cyclosporin A inhibits phosphatase activity of calcineurin. This small molecule also inhibits formation and opening of the mitochondrial permeability transition pore (MPTP).

Alternative Names

Cyclosporine, Antibiotic S 7481F1, Ciclosporin A, Ramihyphin A, CsA, Sandimmune

(3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,2

References

1. Anastasia, L., et al. 2010. Cell Death Diff. 17(8): 1230-1237. PMID: 20168332

2. Woillard, J., et al. 2014. Br J Clin Pharmacol. epub. PMID: 24698009

Product Details
Formula C62H111N11O12
Molecular Weight 1202.61
CAS Number 59865-13-3
Purity >99%
Solubility DMSO, ethanol
Stability and Storage Stable at -20°C. Keep away from direct sunlight.