Dexamethasone

Code Description Price Qty
SM47-25 Dexamethasone, 25 mg £30.00
SM47-250 Dexamethasone, 250 mg £85.00
SM47-500 Dexamethasone, 500 mg £155.00
SM47-1000 Dexamethasone, 1 g £285.00
Dexamethasone

Activity

Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs that has anti-inflammatory and immunosuppressant properties. Dexamethasone is used to treat many inflammatory and autoimmune conditions, such as rheumatoid arthritis and bronchospasm.

Effect

Dexamethasone inhibits induction of nitric oxide synthase. Dexamethasone reduces levels of activated NF-kappaB in immature dendritic cells (DCs) and inhibits differentiation into mature DCs. This biomolecule induces differentiation of human mesenchymal stem cells (MSCs). It also induces autophagy in acute lymphoblastic leukemia (ALL) cell lines.

Alternative Names

Dex

(11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione, 9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione

References

1. Xiao, Y., et al. 2010. J Tissue Eng Regen Med. 4(5): 374-386. PMID: 20058244

2. Ankrum, JA., et al. 2014. Sci Rep. 4: 4645. PMID: 24717973

Product Details
Formula C22H29FO5
Molecular Weight 392.47
CAS Number 50-02-2
Purity >98%
Solubility DMSO
Stability and Storage Stable at -20°C. Keep away from direct sunlight.