Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs that has anti-inflammatory and immunosuppressant properties. Dexamethasone is used to treat many inflammatory and autoimmune conditions, such as rheumatoid arthritis and bronchospasm.
Dexamethasone inhibits induction of nitric oxide synthase. Dexamethasone reduces levels of activated NF-kappaB in immature dendritic cells (DCs) and inhibits differentiation into mature DCs. This biomolecule induces differentiation of human mesenchymal stem cells (MSCs). It also induces autophagy in acute lymphoblastic leukemia (ALL) cell lines.
1. Xiao, Y., et al. 2010. J Tissue Eng Regen Med. 4(5): 374-386. PMID: 20058244
2. Ankrum, JA., et al. 2014. Sci Rep. 4: 4645. PMID: 24717973