Dorsomorphin Dihydrochloride

Code Description Price Qty
SM03-2 Dorsomorphin DiHydrochloride, 2 mg £30.00
SM03-10 Dorsomorphin DiHydrochloride, 10 mg £85.00
SM03-50 Dorsomorphin DiHydrochloride, 50 mg £285.00
SM03-200 Dorsomorphin DiHydrochloride, 200 mg £680.00
Dorsomorphin Dihydrochloride

Exact Amount™

The mg quantity of material provided in the smallest pack size for this product is specified on the vial label to two decimal places. This reduces concentration variation and ensures reproducibility in your experiments.

Activity

Dorsomorphin is a BMP pathway inhibitor, which inhibits bone morphogenetic protein type 1 receptors ACTR-I (ALK2), BMPR-IA (ALK3), and BMPR-IB (ALK 6). Dorsomorphin, also named as AMPK Inhibitor, has also been shown to play role as a potent and selective inhibitor of AMPK, induced by AICAR and metformin.

Effect

Dorsomorphin promotes cardiomyogenesis in mouse embryonic stem cells (ESC) and induces autophagy in cancer cell lines via a mechanism independent of AMPK inhibition.

Alternative Names

AMPK Inhibitor I, BML-275, BMP Inhibitor I, Compound C

6-[4-(2-Piperidin-1-yl-ethoxy)-phenyl)]-3-pyridin-4-yl-pyrrazolo[1,5-a]-pyrimidine dihydrochloride

References

1. Zhou, G., et al. 2001. J. Clin. Invest. 108: 1167-1174. PMID: 11602624

2. Kim, E.K., et al. 2004. J. Biol. Chem. 279: 19970-19976. PMID: 15028725

3. McCullough, L.D., et al., 2005. J. Biol. Chem. 280: 20493-20502. PMID: 15772080

4. Ramamurthy, S. and Ronnett, G.V. 2006. J. Physiol. 574: 85-93. PMID: 16690704

5. Yu, P.B., et al. 2008. Nat. Chem. Biol. 4: 33-41. PMID: 18026094

Product Details
Formula C24H25N5O.2HCl
Molecular Weight 472.41
CAS Number 1219168-18-9
Purity >99%
Solubility DMSO, water
Stability and Storage Stable at -20°C. Keep away from direct sunlight.