Fasudil Hydrochloride
Activity
Fasudil hydrochloride is a cyclic nucleotide-dependent Rho-associated kinase inhibitor. The Rho-kinase (ROCK) mediates vasoconstriction and vascular remodeling.
Effect
Fasudil effectively inhibited ISO-induced heart failure, as evaluated by biometric, hemodynamic, and histological examinations. It has been demonstrated that fasudil decrease human embryonic stem cells (hESC) dissociation-induced apoptosis, increase hESC cloning efficiency and facilitate hESC subcloning after gene transfer.
Alternative Names
HA-1077 hydrochloride, Eril, AT-877
5-(1,4-diazepan-1-ylsulfonyl)isoquinoline hydrochloride
References
1. Watanabe, K., et al. 2007. Nat Biotechnol. 25(6): 681-686. PMID: 17529971
2. Zhang, XZ. 2010. Reprod Biomed Online. 21(1): 26-36. PMID: 20462797
3. O, E., et al. 2011. Int J Mol Med. 28(3): 357-363. PMID: 21567077
| Product Details | |
|---|---|
| Formula | C14H17N3O2S.HCl |
| Molecular Weight | 327.83 |
| CAS Number | 105628-07-7 |
| Purity | >99% |
| Solubility | DMSO, water |
| Stability and Storage | Stable at -20°C. Keep away from direct sunlight. |
