Fasudil Hydrochloride

Code Description Price Qty
SM49-10 Fasudil Hydrochloride, 10 mg £30.00
SM49-50 Fasudil Hydrochloride, 50 mg £85.00
SM49-250 Fasudil Hydrochloride, 250 mg £110.00
SM49-500 Fasudil Hydrochloride, 500 mg £180.00
SM49-1000 Fasudil Hydrochloride, 1 g £740.00
Fasudil Hydrochloride

Activity

Fasudil hydrochloride is a cyclic nucleotide-dependent Rho-associated kinase inhibitor. The Rho-kinase (ROCK) mediates vasoconstriction and vascular remodeling.

Effect

Fasudil effectively inhibited ISO-induced heart failure, as evaluated by biometric, hemodynamic, and histological examinations. It has been demonstrated that fasudil decrease human embryonic stem cells (hESC) dissociation-induced apoptosis, increase hESC cloning efficiency and facilitate hESC subcloning after gene transfer.

Alternative Names

HA-1077 hydrochloride, Eril, AT-877

5-(1,4-diazepan-1-ylsulfonyl)isoquinoline hydrochloride

References

1. Watanabe, K., et al. 2007. Nat Biotechnol. 25(6): 681-686. PMID: 17529971

2. Zhang, XZ. 2010. Reprod Biomed Online. 21(1): 26-36. PMID: 20462797

3. O, E., et al. 2011. Int J Mol Med. 28(3): 357-363. PMID: 21567077

Product Details
Formula C14H17N3O2S.HCl
Molecular Weight 327.83
CAS Number 105628-07-7
Purity >99%
Solubility DMSO, water
Stability and Storage Stable at -20°C. Keep away from direct sunlight.