Forskolin
Exact Amount™
The mg quantity of material provided in the smallest pack size for this product is specified on the vial label to two decimal places. This reduces concentration variation and ensures reproducibility in your experiments.Activity
Forskolin is a cAMP pathway activator, by activating adenylyl cyclase.
Effect
Forskolin allows maintenance of human embryonic stem cells in a naive or ground state similar to mouse embryonic stem cells. Forskolin also enables chemical reprogramming of mouse embryonic fibroblasts to induced pluripotent stem cells, when combined with other small molecules. Forskolin is a vasodilator, which can help in controlling the cause of glaucoma and reduce urinary tract infections.
Alternative Names
Colforsin, Coleonol
[3R-(3α,4aβ,5β,6β,6aα,10α,10aβ,10bα)]-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one
References
1. Seamon, K.B., et al. 1986. Adv Cyclic Nucleotide Protein Phosphorylation Res. 20: 1-150. PMID: 3028083
2. Laurenza, A., et al. 1989. Trends pharmacol. Sci. 10: 442-447. PMID: 2692256
3. De Souza, N.J., et al. 1983. Med Res Rev. 3: 201-219. PMID: 6345959
4. Hanna, J., et al. 2010. Proc Natl Acad Sci USA. 107(20): 9222-9227. PMID: 20442331
5. Hou, P., et al. 2013. Science. 341(6146): 651-654. PMID: 23868920
| Product Details | |
|---|---|
| Formula | C22H34O7 |
| Molecular Weight | 410.5 |
| CAS Number | 66575-29-9 |
| Purity | >99% |
| Solubility | DMSO, ethanol |
| Stability and Storage | Stable at -20°C. Keep away from direct sunlight. |
