GDC-0449

Code Description Price Qty
SM54-5 GDC-0449, 5 mg £30.00
SM54-25 GDC-0449, 25 mg £85.00
SM54-50 GDC-0449, 50 mg £165.00
SM54-200 GDC-0449, 200 mg £465.00
GDC-0449

Exact Amount™

The mg quantity of material provided in the smallest pack size for this product is specified on the vial label to two decimal places. This reduces concentration variation and ensures reproducibility in your experiments.

Activity

GDC-0449 is a potent and specific Hedgehog signaling pathway inhibitor.

Effect

GDC-0449 targets the Hedgehog signaling pathway, blocking the activities of the Hedgehog-ligand cell surface receptors PTCH and/or SMO and suppressing Hedgehog signaling. GDC-0449 prevents multiple ATP-binding cassette (ABC) transporters. GDC-0449 prevents the growth of primary pancreatic xenografts without non-specifically inhibiting pancreatic cell proliferation.

Alternative Names

Vismodegib, HhAntag691

2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide

References

1. Firestone, AJ. and Chen, JK. 2010. ACS Chem Biol. 5(1): 15-34. PMID: 20000447

2. An, SM., et al. 2013. Acta Pharmacol Sin. 34(6): 777-783. PMID: 23708555

Product Details
Formula C19H14Cl2N2O3S
Molecular Weight 421.30
CAS Number 879085-55-9
Purity >99%
Solubility DMSO, ethanol
Stability and Storage Stable at -20°C. Keep away from direct sunlight.