Code Description Price Qty
SM55-2 Geldanamycin, 2 mg $60.00
SM55-10 Geldanamycin, 10 mg $175.00
SM55-25 Geldanamycin, 25 mg $279.00
SM55-50 Geldanamycin, 50 mg $421.00
SM55-250 Geldanamycin, 250 mg $813.00

Exact Amount™

The mg quantity of material provided in the smallest pack size for this product is specified on the vial label to two decimal places. This reduces concentration variation and ensures reproducibility in your experiments.


Geldanamycin is a natural existing HSP90 (Heat Schock Protein 90) inhibitor, specifically disrupts glucocorticoid receptor (GR)/HSP association. The HSP90 chaperone is required for the activation of several families of eukaryotic protein kinases and nuclear hormone receptors, many of which are proto-oncogenic and play a prominent role in cancer.


Geldanamycin has antiproliferative and antitumor effects, as it binds to HSP90, inhibits the HSP90-mediated conformational maturation/refolding reaction. It interferes with cellular stress response. Geldanamycin decrease the expression of hypoxia inducible factor (HIF-1 alpha) in neural stem/progenitor cells.

Alternative Names

Geldanomycin, U-29135, NSC 122750

(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-Hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate


1. Whitesell, L., et al. 1994. Proc Natl Acad Sci USA. 91(18): 8324-8328. PMID: 8078881

2. Xiong, L., et al. 2009. Cell Stress Chaperones. 14(2): 183-192. PMID: 18726712

3. Minuth, WW., et al. 2010. Adv Drug Deliv Rev. 62(7-8): 841-854. PMID: 20122975

Product Details
Formula C29H40N2O9
Molecular Weight 560.64
CAS Number 30562-34-6
Purity >99%
Solubility DMSO
Stability and Storage Stable at -20°C. Keep away from direct sunlight.