Go 6983

Code Description Price Qty
SM20-1 Go 6983, 1 mg £30.00
SM20-5 Go 6983, 5 mg £85.00
SM20-10 Go 6983, 10 mg £155.00
Go 6983

Exact Amount™

The mg quantity of material provided in the smallest pack size for this product is specified on the vial label to two decimal places. This reduces concentration variation and ensures reproducibility in your experiments.

Activity

Go 6983 is a protein kinase C (PKC) inhibitor.

Effect

Go 6983 inhibits intracellular Ca2+ accumulation, suggesting a mechanism for its vasodilator properties. The inhibition of PKC signaling is an efficient strategy to establish and maintain pluripotent rat embryonic stem cells and to facilitate reprogramming of rat embryonic fibroblasts to rat induced pluripotent stem cells.

Alternative Names

Goe 6983

1H-Pyrrole-2,5-dione, 3-[1-[3-(dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

References

1. Young, LG., et al. 2005. Cardiovasc Drug Rev. 23(3): 255-272. PMID: 16252018

2. Chen, J., et al. 2005. Mol Pharmacol. 67(1): 152-162. PMID: 15496505

3. Rajendran, G., et al. 2013. J Biol Chem. 288(34): 24351-24362. PMID: 23846691

Product Details
Formula C26H26N4O3
Molecular Weight 442.51
CAS Number 133053-19-7
Purity >98%
Solubility DMSO
Stability and Storage Stable at -20°C. Keep away from direct sunlight.