Go 6983
Go 6983
Exact Amount™
The mg quantity of material provided in the smallest pack size for this product is specified on the vial label to two decimal places. This reduces concentration variation and ensures reproducibility in your experiments.Activity
Go 6983 is a protein kinase C (PKC) inhibitor.
Effect
Go 6983 inhibits intracellular Ca2+ accumulation, suggesting a mechanism for its vasodilator properties. The inhibition of PKC signaling is an efficient strategy to establish and maintain pluripotent rat embryonic stem cells and to facilitate reprogramming of rat embryonic fibroblasts to rat induced pluripotent stem cells.
Alternative Names
Goe 6983
1H-Pyrrole-2,5-dione, 3-[1-[3-(dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
References
1. Young, LG., et al. 2005. Cardiovasc Drug Rev. 23(3): 255-272. PMID: 16252018
2. Chen, J., et al. 2005. Mol Pharmacol. 67(1): 152-162. PMID: 15496505
3. Rajendran, G., et al. 2013. J Biol Chem. 288(34): 24351-24362. PMID: 23846691
| Product Details | |
|---|---|
| Formula | C26H26N4O3 |
| Molecular Weight | 442.51 |
| CAS Number | 133053-19-7 |
| Purity | >98% |
| Solubility | DMSO |
| Stability and Storage | Stable at -20°C. Keep away from direct sunlight. |
