GSK429286A

Code Description Price Qty
SM21-2 GSK429286A, 2 mg £30.00
SM21-10 GSK429286A, 10 mg £90.00
SM21-50 GSK429286A, 50 mg £440.00
GSK429286A

Exact Amount™

The mg quantity of material provided in the smallest pack size for this product is specified on the vial label to two decimal places. This reduces concentration variation and ensures reproducibility in your experiments.

Activity

GSK429286A is a cell-permeable, selective Rho-associated kinase (ROCK) inhibitor, active for ROCK1 and ROCK2. GSK429286A is a more selective ROCK2 inhibitor than the widely utilized ROCK inhibitor Y-27632 as assessed on kinase-specificity panel, and does not significantly inhibit LRRK2.

Effect

GSK429286A significantly inhibits rat aortic ring dilation and reduces mean arterial pressure in the spontaneously hypertensive rats (SHRs).

Alternative Names

GSK 429286, GSK-429286, dihydropyridone indazole

N-(6-fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-(4-(trifluoromethyl)phenyl)-1,4,5,6-tetrahydropyridine-3-carboxamide

References

1. Nichols, RJ., et al. 2009. Biochem J. 424(1): 47-60. PMID: 19740074

2. Sharon-Frilling, R. and Shenk, T. 2014. Proc Natl Acad Sci USA. 111(12): E1140-1148. PMID: 24616524

Product Details
Formula C21H16F4N4O2
Molecular Weight 432.37
CAS Number 864082-47-3
Purity >98%
Solubility DMSO
Stability and Storage Stable at -20°C. Keep away from direct sunlight.