GX15-070

Code Description Price Qty
SM56-2 GX15-070, 2 mg £30.00
SM56-10 GX15-070, 10 mg £85.00
SM56-50 GX15-070, 50 mg £245.00
SM56-200 GX15-070, 200 mg £980.00
GX15-070

Exact Amount™

The mg quantity of material provided in the smallest pack size for this product is specified on the vial label to two decimal places. This reduces concentration variation and ensures reproducibility in your experiments.

Activity

GX15-070 is a novel Bcl-2 homology domain-3 (BH3) mimetic. It occupies a hydrophobic cleft within the BH3 binding groove of Bcl-2, antagonizing Bcl-2 and thus inducing apoptosis.

Effect

GX15-070 enhances the antimyeloma activity induced by melphalan, dexamethasone, or bortezomib. GX15-070 potentiates TRAIL-mediated apoptosis by unsequestering Bak and Bim from Bcl-2/Bcl-xL or Mcl-1 proteins in PANC-1 and BxPC-3 cells.

Alternative Names

Obatoclax, GX15-070MS

(Z)-2-(5-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-4-methoxy-5H-pyrrol-2-yl)-1H-indole mesylate

References

1. Konopleva, M., et al. 2008, Cancer Research. 68(9): 3413-3420. PMID: 18451169

2. Fan, W., et al. 2011. Cancer Res. 71(13): 4494-4505. PMID: 21555370

3. Ying, S., et al. 2012. Cancer Res. 72(11): 2814-2821. PMID: 22447567

Product Details
Formula C20H19N3O.CH4SO3
Molecular Weight 413.49
CAS Number 803712-79-0
Purity >99%
Solubility DMSO, ethanol
Stability and Storage Stable at -20°C. Keep away from direct sunlight.