GX15-070
Exact Amount™
The mg quantity of material provided in the smallest pack size for this product is specified on the vial label to two decimal places. This reduces concentration variation and ensures reproducibility in your experiments.Activity
GX15-070 is a novel Bcl-2 homology domain-3 (BH3) mimetic. It occupies a hydrophobic cleft within the BH3 binding groove of Bcl-2, antagonizing Bcl-2 and thus inducing apoptosis.
Effect
GX15-070 enhances the antimyeloma activity induced by melphalan, dexamethasone, or bortezomib. GX15-070 potentiates TRAIL-mediated apoptosis by unsequestering Bak and Bim from Bcl-2/Bcl-xL or Mcl-1 proteins in PANC-1 and BxPC-3 cells.
Alternative Names
Obatoclax, GX15-070MS
(Z)-2-(5-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-4-methoxy-5H-pyrrol-2-yl)-1H-indole mesylate
References
1. Konopleva, M., et al. 2008, Cancer Research. 68(9): 3413-3420. PMID: 18451169
2. Fan, W., et al. 2011. Cancer Res. 71(13): 4494-4505. PMID: 21555370
3. Ying, S., et al. 2012. Cancer Res. 72(11): 2814-2821. PMID: 22447567
| Product Details | |
|---|---|
| Formula | C20H19N3O.CH4SO3 |
| Molecular Weight | 413.49 |
| CAS Number | 803712-79-0 |
| Purity | >99% |
| Solubility | DMSO, ethanol |
| Stability and Storage | Stable at -20°C. Keep away from direct sunlight. |
