IM-12

Code Description Price Qty
SM04-2 IM-12, 2 mg $55.00
SM04-10 IM-12, 10 mg $160.00
SM04-25 IM-12, 25 mg $280.00
SM04-100 IM-12, 100 mg $935.00
SM04-500 IM-12, 500 mg $3,605.00
IM-12

Exact Amount™

The mg quantity of material provided in the smallest pack size for this product is specified on the vial label to two decimal places. This reduces concentration variation and ensures reproducibility in your experiments.

Activity

IM-12 is a cell-permeable indolylmaleimide that acts as a Glycogen synthase kinase 3 beta (GSK-3 beta) inhibitor, activating downstream components of canonical Wnt signaling.

Effect

IM-12 significantly increases beta-catenin levels. IM-12 leads to TCF-induction and promotes neuronal differentiation in human neural progenitor cells by activating Wnt pathway. IM-12 when combined with other small molecules supports the self-renewal of naive human embryonic stem cells and maintenance of ground state pluripotency.

Alternative Names

GSK-3beta Inhibitor

3-(4-Fluorophenylethylamino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione

References

1. Schmole, AC., et al. 2010. Bioorg Med Chem. 18(18): 6785-6795. PMID: 20708937

2. Theunissen, TW. et al. 2014. Cell Stem Cell. 15(4): 471-487. PMID: 25090446

Product Details
Formula C22H20FN3O2
Molecular Weight 377.41
CAS Number 1129669-05-1
Purity >98%
Solubility DMSO
Stability and Storage Stable at -20°C. Keep away from direct sunlight.