Irinotecan Hydrochloride Trihydrate
Exact Amount™The mg quantity of material provided in the smallest pack size for this product is specified on the vial label to two decimal places. This reduces concentration variation and ensures reproducibility in your experiments.
Irinotecan hydrochloride trihydrate (CPT 11), a compound within the camptothecin family, is an inhibitor of Topo I (topoisomerase I) involved in cellular DNA replication and transcription. This compound is a prodrug which needs to be transformed by carboxylesterases to its active metabolite SN-38.
As a Topo I inhibitor, Irinotecan inhibits the religation step of the enzyme's normal action, inducing single stranded DNA breaks. These single stranded breaks are then converted to double-stranded breaks within the course of DNA replication which is reported to induce apoptosis or repair mechanisms as a result. Irinotecan has a therapeutic effect in malignant brain tumors, with increased efficacy when combined in neural stem cells therapies.
Camptosar, Topotecin, Campto, Camptothecin 11, CPT-11, CPT 11, U-101440E, PNU-101440E, DQ-2805
(S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate hydro
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