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IWP-2 is an inhibitor of Wnt processing and secretion. It appears that IWP inactivates Porcn function either by directly inhibiting the Porcn active site or by modulating the function of a Porcn regulator.
IWP-2 promotes cardiomyocyte differentiation from human pluripotent stem cells (hPSC). This small molecule also suppresses self-renewal in mouse embryonic stem cells and supports their conversion to epiblast-like stem cells.
Inhibitor of WNT Production-2
1. ten Berge, D., et al. 2011. Nat Cell Biol. 13(9): 1070-1075. PMID: 21841791
2. Chen, B., et al. 2009. Nat Chem Biol. 5(2): 100-107. PMID: 19125156
|Stability and Storage||Stable at -20°C. Keep away from direct sunlight.|