IWP-2
IWP-2
Exact Amount™
The mg quantity of material provided in the smallest pack size for this product is specified on the vial label to two decimal places. This reduces concentration variation and ensures reproducibility in your experiments.Activity
IWP-2 is an inhibitor of Wnt processing and secretion. It appears that IWP inactivates Porcn function either by directly inhibiting the Porcn active site or by modulating the function of a Porcn regulator.
Effect
IWP-2 promotes cardiomyocyte differentiation from human pluripotent stem cells (hPSC). This small molecule also suppresses self-renewal in mouse embryonic stem cells and supports their conversion to epiblast-like stem cells.
Alternative Names
Inhibitor of WNT Production-2
N-(6-methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide
References
1. ten Berge, D., et al. 2011. Nat Cell Biol. 13(9): 1070-1075. PMID: 21841791
2. Chen, B., et al. 2009. Nat Chem Biol. 5(2): 100-107. PMID: 19125156
| Product Details | |
|---|---|
| Formula | C22H18N4O2S3 |
| Molecular Weight | 466.6 |
| CAS Number | 686770-61-6 |
| Purity | >98% |
| Solubility | DMSO |
| Stability and Storage | Stable at -20°C. Keep away from direct sunlight. |
