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KY02111 is a Wnt signaling pathway inhibitor.
KY02111 promotes differentiation of human pluripotent stem cells (hPSC) to cardiomyocytes by inhibiting Wnt signaling in hPSC in a manner that is distinct from that of previously studied Wnt inhibitors. The substantial (98%) differentiation of hPSC to cardiomyocytes with KY02111 is achieved in xeno-free and cytokine-free conditions.
1. Minami, I., et al. 2012. Cell Rep. 2(5): 1448-1460. PMID: 23103164