LY411575
LY411575
Exact Amount™
The mg quantity of material provided in the smallest pack size for this product is specified on the vial label to two decimal places. This reduces concentration variation and ensures reproducibility in your experiments.Activity
LY411575 is a potent gamma secretase inhibitor. It is able to block Notch activation and reduces A beta/42 post treatment (acute or chronic).
Effect
Notch signaling is a pathway known to regulate both differentiation and proliferation of cells in diverse adult tissues. LY411575 has been shown to promote goblet cell differentiation in mice intestine. It has also been observed to promote neural differentiation of mouse embryonic stem cells (ESC).
Alternative Names
LY-411575, LY 411575, LSN-411575
N-2((2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl)-N1-((7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-l-alaninamide
References
1. Curry, CL., et al. 2005. Oncogene. 24(42): 6333-6344. PMID: 15940249
2. Abranches, E., et al. 2009. PLoS One. 4(7): e6286. PMID: 19621087
| Product Details | |
|---|---|
| Formula | C26H23F2N3O4 |
| Molecular Weight | 479.48 |
| CAS Number | 209984-57-6 |
| Purity | >98% |
| Solubility | DMSO |
| Stability and Storage | Stable at -20°C. Keep away from direct sunlight. |
