Code Description Price Qty
SM27-2 PD173074, 2 mg $60.00
SM27-10 PD173074, 10 mg $175.00
SM27-25 PD173074, 25 mg $485.00
SM27-100 PD173074, 100 mg $1,102.00

Exact Amount™

The mg quantity of material provided in the smallest pack size for this product is specified on the vial label to two decimal places. This reduces concentration variation and ensures reproducibility in your experiments.


The fibroblast growth factor receptors (FGFRs) are cell surface receptors with intrinsic tyrosine kinase activity, which is necessary for receptor activation and signal propagation. PD173074 is a potent and selective inhibitor of FGFR tyrosine kinase activity, blocking autophosphorylation of FGFR1 and FGFR3. However, poorly inhibits PDGFR and c-Src and has no effect on EGFR, InsR, MEK, or PKC.


PD173074 inhibits proliferation and differentiation of oligodendrocyte progenitors. PD173074 also blocks tumor growth in H510 and H69 SCLC xenograft models.

Alternative Names

PD 173074, PD-173074



1. Mohammadi, M., et al. 1998. EMBO J. 17(20): 5896-5904. PMID: 9774334

2. Zaragosi, LE., et al. 2006. Stem Cells. 24(11): 2412-2419. PMID: 16840552

3. Ying, QL., et al. 2008. Nature. 453(7194): 519-523. PMID: 18497825

4. Pardo, OE. et al. 2010. Cancer Res. 69(22):8645-8651. PMID: 19903855

Product Details
Formula C28H41N7O3
Molecular Weight 523.67
CAS Number 219580-11-7
Purity >99%
Solubility DMSO, ethanol
Stability and Storage Stable at -20°C. Keep away from direct sunlight.