PD98059
Exact Amount™
The mg quantity of material provided in the smallest pack size for this product is specified on the vial label to two decimal places. This reduces concentration variation and ensures reproducibility in your experiments.Activity
PD98059 is a potent and selective cell permeable inhibitor of MAP kinase (MEK). It selectively blocks the activation of MEK, thereby inhibiting the phosphorylation and the activation of MAP kinase.
Effect
PD98059 inhibits cell growth and reverses the phenotype of ras-transformed BALB3T3 mouse fibroblasts and rat kidney cells. PD98059 inhibits cell growth and proliferation in acute myelogenous leukemia (AML) cell lines and causes G1 arrest by blocking p53-dependent p21 induction. This small molecule also enhances embryonic stem cell (ESC) self-renewal.
Alternative Names
PD 98059, 2′-Amino-3′-methoxyflavone
2-(2-amino-3-methoxyphenyl)-4H-1-Benzopyran-4-one
References
1. Alessi, DR., et al. 1995. J Biol Chem. 270(46): 27489-27494. PMID: 7499206
2. Dudley, DT., et al. 1995. Proc Natl Acad Sci U S A. 92(17): 7686-7689. PMID: 7644477
3. Tsang, F., et al. 1998. Br J Pharmacol. 125(1): 61-68. PMID: 9776345
4. Qi, X., et al. 2004. Proc Natl Acad Sci U S A. 101(16): 6027-6032. PMID: 15075392
5. Kojima, k., et al. 2007. Cancer Res. 67(7): 3210-3219. PMID: 17409429
| Product Details | |
|---|---|
| Formula | C16H13NO3 |
| Molecular Weight | 267.28 |
| CAS Number | 167869-21-8 |
| Purity | >99% |
| Solubility | DMSO, ethanol |
| Stability and Storage | Stable at -20°C. Keep away from direct sunlight. |
