Code Description Price Qty
SM28-2 PD98059, 2 mg $60.00
SM28-10 PD98059, 10 mg $175.00
SM28-25 PD98059, 25 mg $322.00
SM28-50 PD98059, 50 mg $459.00

Exact Amount™

The mg quantity of material provided in the smallest pack size for this product is specified on the vial label to two decimal places. This reduces concentration variation and ensures reproducibility in your experiments.


PD98059 is a potent and selective cell permeable inhibitor of MAP kinase (MEK). It selectively blocks the activation of MEK, thereby inhibiting the phosphorylation and the activation of MAP kinase.


PD98059 inhibits cell growth and reverses the phenotype of ras-transformed BALB3T3 mouse fibroblasts and rat kidney cells. PD98059 inhibits cell growth and proliferation in acute myelogenous leukemia (AML) cell lines and causes G1 arrest by blocking p53-dependent p21 induction. This small molecule also enhances embryonic stem cell (ESC) self-renewal.

Alternative Names

PD 98059, 2′-Amino-3′-methoxyflavone



1. Alessi, DR., et al. 1995. J Biol Chem. 270(46): 27489-27494. PMID: 7499206

2. Dudley, DT., et al. 1995. Proc Natl Acad Sci U S A. 92(17): 7686-7689. PMID: 7644477

3. Tsang, F., et al. 1998. Br J Pharmacol. 125(1): 61-68. PMID: 9776345

4. Qi, X., et al. 2004. Proc Natl Acad Sci U S A. 101(16): 6027-6032. PMID: 15075392

5. Kojima, k., et al. 2007. Cancer Res. 67(7): 3210-3219. PMID: 17409429

Product Details
Formula C16H13NO3
Molecular Weight 267.28
CAS Number 167869-21-8
Purity >99%
Solubility DMSO, ethanol
Stability and Storage Stable at -20°C. Keep away from direct sunlight.