Pifithrin μ
Exact Amount™
The mg quantity of material provided in the smallest pack size for this product is specified on the vial label to two decimal places. This reduces concentration variation and ensures reproducibility in your experiments.Activity
Pifithrin μ selectively interacts with HSP70 and disrupts its association with co-chaperones and substrate proteins. It induces apoptosis and it is cell permeable. Also, inhibits p53 binding to mitochondria by reducing its affinity for antiapoptotic proteins Bcl-2 and Bcl-XL.
Effect
Pifithrin μ rescues cells from lethal γ-irradiation-induced cell death.
Alternative Names
PFTu, NSC 303580, PIF
2-Phenylethynesulfonamide
References
1. Strom, E., et al. 2006. Nat Chem Biol. 2: 474-479. PMID: 16862141
2. Xu, X., et al. 2010. Biotechnol Prog. 26: 781-788. PMID: 20014103
3. Steele, A.J., et al. 2009. Blood. 114: 1217-1225. PMID: 19515722
4. Vaseva, A.V., et al. 2009. Cell Cycle. 8: 1711-1719. PMID: 19411846
5. Drakos, E., et al. 2009. Leukemia. 23: 2290-2299. PMID: 19741726
6. Hagn, F., et al. 2010. J. Biol. Chem. 285: 3439-3450. PMID: 19955567
| Product Details | |
|---|---|
| Formula | C8H7NO2S |
| Molecular Weight | 181.2 |
| CAS Number | 64984-31-2 |
| Purity | >98% |
| Solubility | DMSO |
| Stability and Storage | Stable at -20°C. Keep away from direct sunlight. |
