PTK787

Code Description Price Qty
SM80-5 PTK787, 5 mg $57.00
SM80-25 PTK787, 25 mg $165.00
SM80-100 PTK787, 100 mg $314.00
PTK787

Exact Amount™

The mg quantity of material provided in the smallest pack size for this product is specified on the vial label to two decimal places. This reduces concentration variation and ensures reproducibility in your experiments.

Activity

PTK787 is an inhibitor of VEGFR2/KDR, less potent against VEGFR1/Flt-1, 18-fold against VEGFR3/Flt-4. PTK787 also inhibits Flk, c-Kit and PDGFR-β.

Effect

PTK787 inhibits VEGFR-dependent tumor angiogenesis and EGFR- and RET-dependent tumor cell proliferation and survival. It shows the anti-proliferation effect by inhibiting thymidine incorporation induced by VEGF in HUVECs.

Alternative Names

Vatalanib, CGP-79787, ZK222584

N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine dihydrochloride

References

1. Zangi, L., et al. 2013. Nat Biotechnol. 31(10): 898-907. PMID: 24013197

2. Arbab, AS. 2012. Histol Histopathol. 27(5): 549-557. PMID: 22419019

3. Brander, D., et al. 2013. Leuk Lymphoma. 54(12): 2627-2630. PMID: 23488610

Product Details
Formula C20H15ClN4.2HCl
Molecular Weight 419.73
CAS Number 212141-51-0
Purity >99%
Solubility DMSO, water
Stability and Storage Stable at -20°C. Keep away from direct sunlight.