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Purmorphamine is an agonist of the protein Smoothened (Hh), a key part of the hedgehog signaling pathway, which is involved in bone growth and brain development as well as having a number of other functions in the body.
Purmorphamine has been shown to induce osteogenesis in bone tissue as well as influencing growth and differentiation of neurons in the brain. The EC50 value for differentiation of C3H10T1/2 cells based on alkaline phosphatase expression is 1 µM.
1. Xu, X., et al. 2004. Chem Biol. 11(9): 1229-1238. PMID: 15380183