Code Description Price Qty
SM85-1 Reversine, 1 mg $60.00
SM85-5 Reversine, 5 mg $175.00
SM85-10 Reversine, 10 mg $241.00

Exact Amount™

The mg quantity of material provided in the smallest pack size for this product is specified on the vial label to two decimal places. This reduces concentration variation and ensures reproducibility in your experiments.


Reversine is a novel class of ATP-competitive Aurora kinase inhibitors. Reversine inhibits the phosphorylation of histone H3, a direct downstream target of Aurora kinases. It acts as a selective A3 adenosine receptor antagonist. Reversine functions as a dual inhibitor of MEK1 and nonmuscle myosin II heavy chain. It also acts as an ATP-competitive, reversible and selective inhibitor of ARK-1, ARK-2, and ARK-3.


Reversine is the first organic molecule that has been demonstrated to reverse the cellular differentiation process. It is shown to induce mouse C2C12 myoblast cells to become multipotent mesenchymal progenitor cells, that could then be induced by osteogenic or adipogenic medium to re-differentiate into bone or adipose precursors, respectively. Moreover, reversine has been shown to promote cell reprogramming and induce dedifferentiation of multiple terminally differentiated mesodermal origin cells, and then differentiate into other cell types within mesodermal lineages as well as neuroectodermal.

Alternative Names

2-(4-Morpholinoanilino)-6-cyclohexylaminopurine N'-cyclohexyl-N-(4-morpholinophenyl)-7H-purine-2,6-diamine


1. Chen, S., et al. 2004. J Am Chem Soc. 126(2): 410-411. PMID: 14719906

2. Hu, X., et al. 2012. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 26(9): 1126-1129. PMID: 23057363

3. Lv, X., et al. 2012. J Cell Biochem. 113(12): 3629-3642. PMID: 22821411

Product Details
Formula C21H27N7O
Molecular Weight 393.49
CAS Number 656820-32-5
Purity >98%
Solubility DMSO
Stability and Storage Stable at -20°C. Keep away from direct sunlight.