Ruxolitinib

Code Description Price Qty
SM87-2 Ruxolitinib, 2 mg £30.00
SM87-10 Ruxolitinib, 10 mg £85.00
SM87-25 Ruxolitinib, 25 mg £195.00
SM87-100 Ruxolitinib, 100 mg £625.00
Ruxolitinib

Exact Amount™

The mg quantity of material provided in the smallest pack size for this product is specified on the vial label to two decimal places. This reduces concentration variation and ensures reproducibility in your experiments.

Activity

Ruxolitinib is a JAK inhibitor of JAK1, JAK2, and JAK3. JAKs, or Janus-associated kinases, are tyrosine kinases found in the cytoplasm that are known to active the signaling of certain growth factor receptors and cytokines.

Effect

JAK inhibition with ruxolitinib could work as pretreatment for allogeneic stem cell transplantation in myelofibrosis. Ruxolitinib inhibits erythropoiesis from induced pluripotent stem cells (iPSC), but has less inhibitory effect on the self-renewal of CD34+ hematopoietic progenitors.

Alternative Names

INCB018424, INCB18424, NCB018424, NCB18424

(3R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile

References

1. Stübig, T., et al. 2014. Leukemia. PMID: 24569777

2. Ye, Z., et al. 2014. Stem Cells. 32(1): 269-278. PMID: 24105986

Product Details
Formula C17H18N6
Molecular Weight 306.37
CAS Number 941678-49-5
Purity >99%
Solubility DMSO, ethanol
Stability and Storage Stable at -20°C. Keep away from direct sunlight.