Ruxolitinib
Exact Amount™
The mg quantity of material provided in the smallest pack size for this product is specified on the vial label to two decimal places. This reduces concentration variation and ensures reproducibility in your experiments.Activity
Ruxolitinib is a JAK inhibitor of JAK1, JAK2, and JAK3. JAKs, or Janus-associated kinases, are tyrosine kinases found in the cytoplasm that are known to active the signaling of certain growth factor receptors and cytokines.
Effect
JAK inhibition with ruxolitinib could work as pretreatment for allogeneic stem cell transplantation in myelofibrosis. Ruxolitinib inhibits erythropoiesis from induced pluripotent stem cells (iPSC), but has less inhibitory effect on the self-renewal of CD34+ hematopoietic progenitors.
Alternative Names
INCB018424, INCB18424, NCB018424, NCB18424
(3R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile
References
1. Stübig, T., et al. 2014. Leukemia. PMID: 24569777
2. Ye, Z., et al. 2014. Stem Cells. 32(1): 269-278. PMID: 24105986
| Product Details | |
|---|---|
| Formula | C17H18N6 |
| Molecular Weight | 306.37 |
| CAS Number | 941678-49-5 |
| Purity | >99% |
| Solubility | DMSO, ethanol |
| Stability and Storage | Stable at -20°C. Keep away from direct sunlight. |
