SAHA

Code Description Price Qty
SM88-10 SAHA, 10 mg £30.00
SM88-50 SAHA, 50 mg £85.00
SM88-250 SAHA, 250 mg £115.00
SM88-500 SAHA, 500 mg £170.00
SM88-1000 SAHA, 1 g £340.00
SAHA

Activity

SAHA (suberoylanilide hydroxamic acid) is a potent, reversible pan-histone deacetylase (HDAC) inhibitor. It inhibits both class I and class II HDACs.

Effect

Experiments suggest that SAHA causes morphological changes, such as enlargement and flattening of the cytoplasm, resulting in growth inhibition. SAHA alters gene transcription and induces cell cycle arrest and/or apoptosis in a wide variety of transformed cells. It suppresses cell growth in a range of cancer cell lines, induces apoptosis in cutaneous T-cell lymphoma cells in-vitro. This small molecule improves reprogramming efficiency after transduction of iPSC transcription factors in mouse embryonic fibroblasts.

Alternative Names

MK-0683, Vorinostat, Suberoylanilide Hydroxamic Acid,Suberanilohydroxamic Acid, Zolinza

N-Hydroxy-N'-phenyloctanediamide

References

1. Butler, LM., et al. 2000. Cancer Res. 60(18): 5165-5170. PMID: 11016644

2. Huangfu, D., et al. 2008. Nat Biotechnol. 26(7): 795-797. PMID: 18568017

3. Zhang, Y., et al. 2012. J Cell Sci. 125(Pt 23): 5609-5620. PMID: 23420199

4. Ma, T., et al. 2013. Circ Res. 112(3): 562-574. PMID: 23371904

Product Details
Formula C14H20N2O3
Molecular Weight 264.32
CAS Number 149647-78-9
Purity >99%
Solubility DMSO, ethanol
Stability and Storage Stable at -20°C. Keep away from direct sunlight.