Exact Amount™The mg quantity of material provided in the smallest pack size for this product is specified on the vial label to two decimal places. This reduces concentration variation and ensures reproducibility in your experiments.
SB203580 is a specific inhibitor of p38-MAPK pathway. SB203580 also inhibits protein kinase B (PKB, also known as Akt) and TLR signaling pathway.
SB203580 inhibits the IL-2-induced proliferation of primary human T cells, murine CT6 T cells, or BAF F7 B cells with an IC50 of 3 - 5 µM. SB203580 suppresses the development of endometriosis by down-regulating proinflammatory cytokines and proteolytic factors in a mouse model. It is a new reversal agent of P-glycoprotein-mediated multidrug resistance.
RWJ 64809, PB 203580
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3. Jarnicki, AG., et al. 2008. J Immunol. 180(6): 3797-3806. PMID: 18322186
|Stability and Storage||Stable at -20°C. Keep away from direct sunlight.|