Code Description Price Qty
SM32-2 SB203580, 2 mg $60.00
SM32-10 SB203580, 10 mg $175.00
SM32-50 SB203580, 50 mg $360.00
SM32-100 SB203580, 100 mg $530.00

Exact Amount™

The mg quantity of material provided in the smallest pack size for this product is specified on the vial label to two decimal places. This reduces concentration variation and ensures reproducibility in your experiments.


SB203580 is a specific inhibitor of p38-MAPK pathway. SB203580 also inhibits protein kinase B (PKB, also known as Akt) and TLR signaling pathway.


SB203580 inhibits the IL-2-induced proliferation of primary human T cells, murine CT6 T cells, or BAF F7 B cells with an IC50 of 3 - 5 µM. SB203580 suppresses the development of endometriosis by down-regulating proinflammatory cytokines and proteolytic factors in a mouse model. It is a new reversal agent of P-glycoprotein-mediated multidrug resistance.

Alternative Names

RWJ 64809, PB 203580



1. Cuenda, A., et al. 1995. FEBS Lett. 364(2): 229-233. PMID: 7750577

2. Lali, FV., et al. 2000. J Biol Chem. 275(10): 7395-7402. PMID: 10702313

3. Jarnicki, AG., et al. 2008. J Immunol. 180(6): 3797-3806. PMID: 18322186

Product Details
Formula C21H16FN3OS
Molecular Weight 377.43
CAS Number 152121-47-6
Purity >99%
Solubility DMSO
Stability and Storage Stable at -20°C. Keep away from direct sunlight.