Code Description Price Qty
SM41-2 SP600125, 2 mg $60.00
SM41-10 SP600125, 10 mg $175.00
SM41-50 SP600125, 50 mg $241.00
SM41-100 SP600125, 100 mg $360.00
SM41-300 SP600125, 300 mg $421.00

Exact Amount™

The mg quantity of material provided in the smallest pack size for this product is specified on the vial label to two decimal places. This reduces concentration variation and ensures reproducibility in your experiments.


SP600125 is a potent, selective and reversible inhibitor of the three JNK enzymes (c-Jun N-terminal kinases). Inhibition is competitive with respect to ATP, and over 300-fold more selective for JNK as compared to ERK1 and p38-2 MAP kinases. SP600125 was shown to cause a dose-dependent inhibition of the phosphorylation of c-Jun, and thereby the expression of inflammatory genes COX-2, IFN-gamma, IL-2 and TNF-alpha.


SP600125 blocks the activation and differentiation of primary human CD4 cell cultures. SP600125 has also been shown to prevent apoptosis in an array of cell types, and it inhibits autophagy in HeLa cells.

Alternative Names

1,9-Pyrazoloanthrone, Anthrapyrazolone, JNK Inhibitor II, SAPK Inhibitor II



1. Wang, Y., et al. 2007. Life Sci. 80(22): 2067-2075. PMID: 17459422

2. Bennett, BL., et al. 2001. Proc Natl Acad Sci U S A. 98(24): 13681-13686. PMID: 11717429

Product Details
Formula C14H8N2O
Molecular Weight 220.23
CAS Number 129-56-6
Purity >99%
Solubility DMSO
Stability and Storage Stable at -20°C. Keep away from direct sunlight.