Tandutinib
Activity
Tandutinib is a piperazinyl quinazoline receptor tyrosine kinase inhibitor. Tandutinib inhibits the autophosphorylation of Flt-3/Flk-2 (FMS-Like Tyrosine kinase-3), c-KIT and PDGF (platelet-derived growth factor) receptor tyrosine kinases. Tandutinib is an inhibitor of PDGFR-β.
Effect
Tandutinib inhibits cellular proliferation and induces apoptosis. Tandutinib works as a stem-like cells targeted agent to increase efficiency of anticancer drugs and it has antineoplastic activity.
Alternative Names
MLN518, CT53518, D06005
4-[6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-[4-(1-methylethoxy)phenyl]-1-piperazinecarboxamide
References
1. Griswold, IJ., et al. 2004. Blood. 104(9): 2912-2918. PMID: 15242881
2. Brownlow, N., et al. 2008. Leukemia. 22(7): 1452-1453. PMID: 18185521
3. Zhao, XQ., et al. 2013. Eur J Pharm Sci. 49(3): 441-450. PMID: 23619284
| Product Details | |
|---|---|
| Formula | C31H42N6O4 |
| Molecular Weight | 562.70 |
| CAS Number | 387867-13-2 |
| Purity | >98% |
| Solubility | Ethanol |
| Stability and Storage | Stable at -20°C. Keep away from direct sunlight. |
